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Titolo:
Early biochemical indicators of hypoxic-ischemic encephalopathy after birth asphyxia
Autore:
Nagdyman, N; Komen, W; Ko, HK; Muller, C; Obladen, M;
Indirizzi:
Humboldt Univ, Charite Univ Hosp, Dept Neonatol, D-13353 Berlin, Germany Humboldt Univ Berlin Germany D-13353 t Neonatol, D-13353 Berlin, Germany Humboldt Univ, Charite Univ Hosp, Inst Lab Med, D-13353 Berlin, Germany Humboldt Univ Berlin Germany D-13353 st Lab Med, D-13353 Berlin, Germany
Titolo Testata:
PEDIATRIC RESEARCH
fascicolo: 4, volume: 49, anno: 2001,
pagine: 502 - 506
SICI:
0031-3998(200104)49:4<502:EBIOHE>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURON-SPECIFIC ENOLASE; FULL-TERM INFANTS; CEREBRAL ENERGY FAILURE; S-100 PROTEIN; CEREBROSPINAL-FLUID; NEWBORN-INFANTS; CARDIOPULMONARY BYPASS; PERINATAL ASPHYXIA; PROGNOSTIC VALUE; BB ISOENZYME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Nagdyman, N Humboldt Univ, Charite Univ Hosp, Dept Neonatol, Augustenburger Pl 1, D-13353 Berlin, Germany Humboldt Univ Augustenburger Pl 1 Berlin Germany D-13353 many
Citazione:
N. Nagdyman et al., "Early biochemical indicators of hypoxic-ischemic encephalopathy after birth asphyxia", PEDIAT RES, 49(4), 2001, pp. 502-506

Abstract

Hypoxic-ischemic encephalopathy (HIE) after perinatal asphyxia is a condition in which serum concentrations of brain-specific biochemical markers maybe elevated. Neuroprotective interventions in asphyxiated newborns requireearly indicators of brain damage to initiate therapy. We examined brain-specific creatine kinase (CK-BB), protein S-100, and neuron-specific enolase in cord blood and 2, 6, 12, and 24 h after birth in 29 asphyxiated and 20 control infants. At 2 h after birth, median (quartiles) serum CK-BB concentration was 10.0 Un (6.0-13.0 U/L) in control infants, 16.0 U/L (13.0-23.5 U/L) in infants with no or mild HIE, and 46.5 U/L (21.4-83.0 U/L) in infants with moderate or severe HIE. Serum protein S-100 was 1.6 mug/L (1.4-2.5 mug/L) in control infants, 2.9 mug/L (1.8-4.7 mug/L) in asphyxiated infants with no or mild HIE, and 17.0 mug/L (3.2-34.1 mug/L) in infants with moderateor severe HIE 2 h after birth. No significant difference was detectable inserum neuron-specific enolase between infants with no or mild and moderateor severe HIE 2 and 6 h after birth. A combination of serum protein S-100 (cutoff value, 8.5 mug/L) and CK-BB (cutoff value, 18.8 U/L) 2 h after birth had the highest predictive value (83%) and specificity (95%) of predicting moderate and severe HIE. Cord blood pH (cutoff value, <6.9) and cord blood base deficit (cutoff value, >17 mM) increase the predictive values of protein S-100 and CK-BB. We conclude that elevated serum concentrations of protein S-100 and CK-BB reliably indicate moderate and severe HIE as early as 2 h after birth.

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Documento generato il 31/03/20 alle ore 08:58:10