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Titolo:
Maternal protein restriction suppresses the newborn renin-angiotensin system and programs adult hypertension in rats
Autore:
Woods, LL; Ingelfinger, JR; Nyengaard, JR; Rasch, R;
Indirizzi:
Oregon Hlth Sci Univ, Div Nephrol, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 ephrol, Portland, OR 97201 USA Massachusetts Gen Hosp, Pediat Nephrol Unit, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 rol Unit, Boston, MA 02114 USA Aarhus Univ, Inst Anat, Dept Cell Biol, DK-8000 Aarhus, Denmark Aarhus Univ Aarhus Denmark DK-8000 pt Cell Biol, DK-8000 Aarhus, Denmark Aarhus Univ, Stereol Res Lab, DK-8000 Aarhus, Denmark Aarhus Univ AarhusDenmark DK-8000 reol Res Lab, DK-8000 Aarhus, Denmark
Titolo Testata:
PEDIATRIC RESEARCH
fascicolo: 4, volume: 49, anno: 2001,
pagine: 460 - 467
SICI:
0031-3998(200104)49:4<460:MPRSTN>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTOLIC BLOOD-PRESSURE; CORONARY HEART-DISEASE; BIRTH-WEIGHT; CARDIOVASCULAR-DISEASE; FETAL EXPOSURE; RENAL GROWTH; 11-BETA-HYDROXYSTEROID DEHYDROGENASE; CONVERTING ENZYME; GENE-EXPRESSION; PREGNANCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Woods, LL Oregon Hlth Sci Univ, Div Nephrol, L463,3181 SW Sam Jackson Pk Rd, Portland, OR 97201 USA Oregon Hlth Sci Univ L463,3181 SW Sam Jackson Pk Rd Portland OR USA 97201
Citazione:
L.L. Woods et al., "Maternal protein restriction suppresses the newborn renin-angiotensin system and programs adult hypertension in rats", PEDIAT RES, 49(4), 2001, pp. 460-467

Abstract

Restriction of maternal protein intake during rat pregnancy produces offspring that are hypertensive in adulthood, but the mechanisms are not well understood. Our purpose was to determine whether this adult hypertension could be programmed during development by suppression of the fetal/newborn renin-angiotensin system (RAS) and a consequent reduction in nephron number. Pregnant rats were fed a normal protein (19%, NP) or low-protein (8.5%, LP) diet throughout gestation. Birth weight was reduced by 13% (p < 0.0005), andthe kidney/body weight ratio was reduced in LP pups. Renal renin mRNA levels were significantly reduced in newborn LP pups; renal renin concentrationand renin immunostaining were suppressed. Renal tissue angiotensin II levels were also suppressed in newborn LP (0.079 <plus/minus> 0.002 ng/mg, LP versus 0.146 +/- 0.016 ng/mg, NP, p < 0.01). Mean arterial pressure in conscious, chronically instrumented adult offspring (21 wk) was higher in LP (135 <plus/minus> 1 mm Hg, LP versus 126 +/- 1 mm Hg, NP, p < 0.00007), and GFR normalized to kidney weight was reduced in LP (p < 0.04). The number of glomeruli per kidney was lower in adult LP offspring (21,567 +/- 1,694, LP versus 28,917 +/- 2,342, NP, p < 0.03), and individual glomerular volume washigher (1.81 <plus/minus> 0.16 10(6) mum(3), LP versus 1.11 +/- 0.10 10(6)mum(3), NP, p < 0.005); the total volume of all glomeruli per kidney was not significantly different.. Thus, perinatal protein restriction in the ratsuppresses the newborn intrarenal RAS and leads to a reduced number of glomeruli, glomerular enlargement, and hypertension in the adult.

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Documento generato il 28/11/20 alle ore 12:37:57