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Titolo:
The effect of genotype on sensitivity to electroacupuncture analgesia
Autore:
Wan, Y; Wilson, SG; Han, JS; Mogil, JS;
Indirizzi:
Univ Illinois, Dept Psychol, Champaign, IL 61820 USA Univ Illinois Champaign IL USA 61820 ept Psychol, Champaign, IL 61820 USA Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100083, Peoples R China Peking Univ Beijing Peoples R China 100083 ijing 100083, Peoples R China Univ Illinois, Neurosci Program, Champaign, IL 61820 USA Univ Illinois Champaign IL USA 61820 sci Program, Champaign, IL 61820 USA
Titolo Testata:
PAIN
fascicolo: 1-2, volume: 91, anno: 2001,
pagine: 5 - 13
SICI:
0304-3959(200103)91:1-2<5:TEOGOS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
INBRED MOUSE STRAINS; GENETIC CORRELATIONS; MORPHINE ANALGESIA; ORPHANIN FQ; PAIN; CHOLECYSTOKININ; ACUPUNCTURE; NOCICEPTION; INHIBITION; RESPONSES;
Keywords:
antinociception; pain; acupuncture; mice; inbred strains; genetic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Mogil, JS Univ Illinois, Dept Psychol, 603 E Daniel St, Champaign, IL 61820 USA Univ Illinois 603 E Daniel St Champaign IL USA 61820 L 61820 USA
Citazione:
Y. Wan et al., "The effect of genotype on sensitivity to electroacupuncture analgesia", PAIN, 91(1-2), 2001, pp. 5-13

Abstract

Individual differences in sensitivity to pain and analgesia are well appreciated, and increasing evidence has pointed towards a role of inherited genetic factors in explaining some proportion of such variability. It has longbeen known by practitioners of acupuncture, an ancient modality of analgesia, that some patients are 'responders' and others 'non-responders. ' The present research was aimed at defining the inherited genetic influence on acupuncture analgesia in the mouse, using 10 common inbred strains. Two pairs of metallic needles were inserted into acupoints ST 36 and SP 6, fixed in situ and then connected to the output channel of an electric pulse generator. Electroacupuncture (EA) parameters were set as constant current output (intensity: 1.0-1.5-2.0 mA, 10 min each; frequency. 2 or 100 Hz) with alteration of a positive and negative square wave, 0.3 ms in pulse width. Tail-flick latencies evoked by radiant heat were measured before, during and after EA stimulation. Narrow-sense heritability estimates of 2 and 100 Hz EA were0.37 and 0.16, respectively. We found that the C57BL/10 strain was the most sensitive, and the SM strain was the least sensitive to both 2 and 100 HzEA. However, the relative sensitivities of other strains to these two EA frequencies suggested some genetic dissociation between them as well. These results demonstrate a role of inherited genetic factors in EA sensitivity ill the mouse, although the low-to-moderate heritability estimates suggest that environmental factors may be of greater importance in predicting who will benefit from this analgesic modality. (C) 2001 International Associationfor the Study of Pain. Published by Elsevier Science B.V. All rights reserved.

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Documento generato il 31/03/20 alle ore 18:56:14