Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Impaired pancreatic secretion in severely malnourished patients is a consequence of primary pancreatic dysfunction
Autore:
Winter, TA; Marks, T; Callanan, M; OKeefe, SJD; Bridger, S;
Indirizzi:
Groote Schuur Hosp, Gastrointestinal Clin, ZA-7925 Cape Town, South AfricaGroote Schuur Hosp Cape Town South Africa ZA-7925 ape Town, South Africa
Titolo Testata:
NUTRITION
fascicolo: 3, volume: 17, anno: 2001,
pagine: 230 - 235
SICI:
0899-9007(200103)17:3<230:IPSISM>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTRIC-ACID SECRETION; ENZYME SECRETION; CHOLECYSTOKININ-OCTAPEPTIDE; GALLBLADDER CONTRACTION; PLASMA CHOLECYSTOKININ; AMINO-ACIDS; FATTY-ACIDS; HUMANS; RESPONSES; RELEASE;
Keywords:
malnutrition; pancreatic enzyme secretion; gastric acid secretion; gut mucosa; parietal cell; pancreatic acinar cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Winter, TA Groote Schuur Hosp, Gastrointestinal Clin, ZA-7925 Cape Town, South Africa Groote Schuur Hosp Cape Town South Africa ZA-7925 outh Africa
Citazione:
T.A. Winter et al., "Impaired pancreatic secretion in severely malnourished patients is a consequence of primary pancreatic dysfunction", NUTRITION, 17(3), 2001, pp. 230-235

Abstract

Severe undernutrition has been associated with reduced secretions of gastric acid and pancreatic enzymes. This may be the result of an impaired gut mucosal response to food and primary gastric parietal and pancreatic acinar cell secretory dysfunction as a consequence of the poor nutritional state. To investigate the relative contributions of these factors, severely undernourished patients underwent enteral-meal-stimulated (ES; n = 7) or intravenous hormone (pentagastrin and cholecystokinin-8)-stimulated (HS; n = 12) gastric acid and pancreatic enzyme secretion before and after a period of nutritional support. Results were evaluated in comparison with normal healthy control subjects (ES = 7, HS = 10). In the control subjects, enteral-meal and cholecystokinin-8 stimulation resulted in similar outputs of the pancreatic enzymes amylase (2213 versus 2305 U/h), lipase (84.93 versus 118.6 U/h), and trypsin (498.9 versus 341.4 U/h), whereas acid output was significantly lower in the ES group (10.90 versus 25.53 mEq/h: P < 0.01), Compared with controls, malnourished groups had significantly reduced secretions of amylase (ES = 870.1 U/h, HS = 686.5 U/h; P < 0.02), lipase (ES = 30.68 U/h, HS= 25.96 U/h; P ( 0.02). and trypsin (ES = 175.6 U/h, HS = 109.3 U/h; P ( 0.01), The response to enteral-meal or CCK-X stimulation was comparable. Gastric acid was similarly reduced in the undernourished patients (ES = 4.39 mEq/h, HS = 5.04 mEq/h; P < 0.01). After refeeding, secretion of amylase (ES= 2351 U/h, HS = 2228 U/h) and lipase (ES = 58.83 U/h, HS = 84.91 U/h) improved to levels not significantly different from controls, whereas trypsin (ES = 226.4 U/h, HS = 213.1 U/h: P <0.03) and acid secretion (ES = 3.52 mEq/h, HS = 11.85 mEq/h: P ( 0.01) remained significantly impaired. Severe undernutrition was associated with primary gastric parietal and pancreatic acinar cell dysfunction, which, at least in the case of pancreatic enzymes, appeared to be the determining factor controlling secretion in these patients, Nutrition 2001:17:230-235. (C) Elsevier Science Inc. 2001.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 12:20:16