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Titolo:
Plasma and brain methamphetamine concentrations neonatal rats
Autore:
Cappon, GD; Vorhees, CV;
Indirizzi:
Childrens Hosp Res Fdn, Div Dev Biol, Cincinnati, OH 45229 USA Childrens Hosp Res Fdn Cincinnati OH USA 45229 , Cincinnati, OH 45229 USA
Titolo Testata:
NEUROTOXICOLOGY AND TERATOLOGY
fascicolo: 1, volume: 23, anno: 2001,
pagine: 81 - 88
SICI:
0892-0362(200101/02)23:1<81:PABMCN>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
EARLY POSTNATAL-DEVELOPMENT; ACOUSTIC STARTLE; SUBSTITUTED AMPHETAMINES; INDUCED NEUROTOXICITY; GENETIC-DIFFERENCES; LEARNING-DEFICITS; INDUCED DEPLETION; C57BL/6J MOUSE; EXPOSURE; DOPAMINE;
Keywords:
methamphetamine; neonatal rats; brain methamphetamine concentrations; plasma methamphetamine concentrations; Sprague-Dawley rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Vorhees, CV Childrens Hosp Res Fdn, Div Dev Biol, 3333 Burnet Ave, Cincinnati, OH 45229 USA Childrens Hosp Res Fdn 3333 Burnet Ave Cincinnati OH USA 45229
Citazione:
G.D. Cappon e C.V. Vorhees, "Plasma and brain methamphetamine concentrations neonatal rats", NEUROTOX T, 23(1), 2001, pp. 81-88

Abstract

D-Methamphetamine (D-MPI) treatment during the neonatal period has been shown to induce acoustic startle hyperreactivity and Morris maze spatial learning deficits, but not to significantly affect Cincinnati maze sequential learning. In order to characterize the internal dose in these experiments, MA was measured in plasma and brain of neonatal rats at one of two ages, andusing one of three dose schedules, two of which were selected to be representative of those used in previously published neurobehavioral studies. Plasma parameters showed few age and dose-frequency effects; however, brain concentrations showed more consistent age-dependent effects. Brain area underthe concentration (AUC) values were consistently higher, regardless of dosing schedule, in offspring treated on postnatal day (P) 1 compared to thosetreated on P11. Previous results with the multiple-dose schedules have shown that Morris maze spatial learning deficits only occur in those exposed beginning on P11, whereas acoustic startle hyperreactivity is associated with exposure beginning on either P1 or P11. The pharmacokinetic parameters did not predict the long-term spatial learning and memory effects of neonatalMA administration, nor are they well correlated to the acoustic startle effects. The plasma concentrations obtained in rats are within the range for human MA abusers based on extrapolations from human low-dose values to those expected for heavy users. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 13:20:09