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Titolo:
Cochlear pathology induced by styrene
Autore:
Lataye, R; Campo, P; Barthelemy, C; Loquet, G; Bonnet, P;
Indirizzi:
Inst Natl Rech & Secur, Lab Neurotoxicite, F-54501 Vandoeuvre Nancy, France Inst Natl Rech & Secur Vandoeuvre Nancy France F-54501 vre Nancy, France
Titolo Testata:
NEUROTOXICOLOGY AND TERATOLOGY
fascicolo: 1, volume: 23, anno: 2001,
pagine: 71 - 79
SICI:
0892-0362(200101/02)23:1<71:CPIBS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT COCHLEA; HEARING DEFICIT; OTOTOXICITY; FREQUENCY; TOLUENE; NERVE; CELLS; AGE;
Keywords:
styrene; ototoxicity; cochlea; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Campo, P Inst Natl Rech & Secur, Lab Neurotoxicite, Ave Bourgogne,BP 27, F-54501 Vandoeuvre Nancy, France Inst Natl Rech & Secur Ave Bourgogne,BP 27 Vandoeuvre Nancy France F-54501
Citazione:
R. Lataye et al., "Cochlear pathology induced by styrene", NEUROTOX T, 23(1), 2001, pp. 71-79

Abstract

Hair cells, spiral fibers and spiral ganglion cells (SGCs) coming from cochleae of styrene-treated Long-Evans rats were counted in order to assess the extent and location of the cochlear injury after the solvent inhalation. If the hair cells, and more specifically the outer hair cells (OHCs), were undoubtedly the first targets of inhaled styrene, the histological results of the present study would seem to indicate that neurons of the spiral ganglion were also injured with increasing styrene doses. The degenerative process of SGCs and spiral fibers within the osseous lamina was predominant in the middle and mid-basal turn. The electrophysiological data, obtained by recording near-field potentials from the inferior colliculus, reflected the damages of the SGCs and fibers but were not consistent with the histopathological data of the organ of Corti. Because of the weak correlation between the styrene-induced injury at the level of the organ of Corti and that induced at the level of the spiral ganglion, it is likely that two different intoxication routes exist within the cochlea. Such an assumption is discussedin the present paper. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 16:04:45