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Titolo:
Neonatal dexamethasone on Day 7 in rats causes behavioral alterations reflective of hippocampal, but not cerebellar, deficits
Autore:
Ferguson, SA; Paule, MG; Holson, RR;
Indirizzi:
US FDA, Div Neurotoxicol, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA USFDA Jefferson AR USA 72079 tl Ctr Toxicol Res, Jefferson, AR 72079 USA
Titolo Testata:
NEUROTOXICOLOGY AND TERATOLOGY
fascicolo: 1, volume: 23, anno: 2001,
pagine: 57 - 69
SICI:
0892-0362(200101/02)23:1<57:NDOD7I>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL RESPONSE DIFFERENTIATION; ACOUSTIC STARTLE; CORTICOSTERONE; GLUCOCORTICOIDS; STRESS; BRAIN; PERFORMANCE; LACTATION; CORTISOL; PLAY;
Keywords:
glucocorticoid; dexamethasone; activity; water maze;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Ferguson, SA US FDA, Div Neurotoxicol, Natl Ctr Toxicol Res, HFT-132,3900 NCTR Rd, Jefferson, AR 72079 USA US FDA HFT-132,3900 NCTR Rd Jefferson AR USA 72079 72079 USA
Citazione:
S.A. Ferguson et al., "Neonatal dexamethasone on Day 7 in rats causes behavioral alterations reflective of hippocampal, but not cerebellar, deficits", NEUROTOX T, 23(1), 2001, pp. 57-69

Abstract

Developmental glucocorticoid treatment in rats has been shown to cause body and brain weight decrements concurrent with behavioral alterations. Here,Sprague-Dawley rats were treated with the synthetic glucocorticoid, dexamethasone (DEX), on postnatal day (PND) 7 (1.5 mg/kg, sc, injected in the morning and afternoon). Behavioral assessments of negative geotaxis, locomotoractivity (open field, maze exploration, residential running wheel, residential figure 8 maze), open-field activity response to amphetamine, acoustic startle, prepulse inhibition (PPT) of acoustic startle, juvenile play behavior, anxiety (emergence tests), motor coordination (rotarod performance), spatial learning (Morris water maze and food-reinforced complex maze), and operant performance (time estimation and response inhibition) were assessed in male rats. Body weight was decreased beginning at PND 43 until sacrificeon PND 127. Whole and regional brain weights were less, especially hippocampus, cerebellum, brainstem, and cortical remnant. Indications of delayed development were apparent; specifically, DEX-treated rats took significantlylonger to turn on PND 8, but not PND 9, in the negative geotaxis test. DEXtreatment induced deficits in the Morris water maze that were similar to hippocampal deficits. Open-field activity changes were inconsistent; however, DEX-treated rats were hyperactive during the dark period in running wheeltests. There were no indications of changes in reactivity or emotionality. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:30:51