Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Comparing cognitive and screening tests for neurotoxicity - Effects of acute chlorpyrifos on visual signal detection and a neurobehavioral test battery in rats
Autore:
Bushnell, PJ; Moser, VC; Samsam, TE;
Indirizzi:
US EPA, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA US EPA Res Triangle Pk NC USA 27711 es Lab, Res Triangle Pk, NC 27711 USA
Titolo Testata:
NEUROTOXICOLOGY AND TERATOLOGY
fascicolo: 1, volume: 23, anno: 2001,
pagine: 33 - 44
SICI:
0892-0362(200101/02)23:1<33:CCASTF>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTIONAL OBSERVATIONAL BATTERY; CHOLINESTERASE INHIBITION; LOCOMOTOR-ACTIVITY; ORAL CHLORPYRIFOS; PERFORMANCE; BEHAVIOR; ANIMALS; MICE; VALIDATION; TOLERANCE;
Keywords:
attention; behavioral screening; chlorpyrifos; functional observational battery; motor activity; organophosphate; signal detection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Bushnell, PJ US EPA, Div Neurotoxicol, Natl Hlth & Environm Effects Res Lab, MD-74B, Res Triangle Pk, NC 27711 USA US EPA MD-74B Res Triangle Pk NC USA 27711 e Pk, NC 27711 USA
Citazione:
P.J. Bushnell et al., "Comparing cognitive and screening tests for neurotoxicity - Effects of acute chlorpyrifos on visual signal detection and a neurobehavioral test battery in rats", NEUROTOX T, 23(1), 2001, pp. 33-44

Abstract

It is often assumed that cognitive function is more sensitive to neurotoxic chemicals than are the unconditioned behaviors employed in neurobehavioral screens; however, direct comparisons of the sensitivity of these test methods are lacking. The present studies were conducted to compare the effectsof the widely used cholinesterase-inhibiting insecticide, chlorpyrifos (O,O'-diethyl O-3,5,6-trichloro-2-pyridyl phosphorothionate, CPF), on a visualsignal detection task (SDT) with its effects on a neurobehavioral test battery. Adult male Long-Evans rats were trained to perform the SDT, dosed with CPF, and then assessed with both test instruments. Oral CPF (50 mg/kg) impaired signal detection for 8 days, and subcutaneous CPF (250 mg/kg) did sofor 4 weeks. CPF (30 and 50 mg/kg po and 250 mg/kg sc) also lowered activity in the test battery for up to 18 days. Thus, CPF impaired attention and altered behavior in the test battery in the same dose ranges under two verydifferent dosing scenarios. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 12:50:18