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Titolo:
The role of desensitisation in decay time of miniature endplate currents in frogs Rana ridibunda and Rana temporaria
Autore:
Giniatullin, RA; Talantova, MV; Vyskocil, F;
Indirizzi:
Acad Sci Czech Republ, Inst Physiol, CR-14220 Prague, Czech Republic Acad Sci Czech Republ Prague Czech Republic CR-14220 gue, Czech Republic Charles Univ, Fac Sci, Dept Anim Physiol & Dev Biol, Prague, Czech Republic Charles Univ Prague Czech Republic l & Dev Biol, Prague, Czech Republic
Titolo Testata:
NEUROSCIENCE RESEARCH
fascicolo: 3, volume: 39, anno: 2001,
pagine: 287 - 292
SICI:
0168-0102(200103)39:3<287:TRODID>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONQUANTAL ACETYLCHOLINE-RELEASE; MOUSE NEUROMUSCULAR-JUNCTION; INTACT CHOLINESTERASE; QUANTAL RELEASE; DESENSITIZATION; MUSCLE; DIAPHRAGM; MEMBRANE; RECEPTOR; TRANSMITTER;
Keywords:
frog; quantal release; desensitisation; miniature endplate potential; acetylcholine receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Vyskocil, F Acad Sci Czech Republ, Inst Physiol, Videnska 1083, CR-14220 Prague, CzechRepublic Acad Sci Czech Republ Videnska 1083 Prague Czech Republic CR-14220
Citazione:
R.A. Giniatullin et al., "The role of desensitisation in decay time of miniature endplate currents in frogs Rana ridibunda and Rana temporaria", NEUROSCI RE, 39(3), 2001, pp. 287-292

Abstract

A new comparative characteristic of endplate microphysiology has been introduced. It is the feasibility of receptors to become desensitised as demonstrated on two frog species, Rana temporaria and Rana ridibunda: the decay times (tau (MEPC)) of single quantum miniature endplate currents (MEPCs) in the sartorius muscles of both species were about 1 ms and were not affectedby the desensitisation-promoting agent proadifen when AChE was active. However: when the desensitisation was induced by anticholinesterase neostigmine and promoted by proadifen, the prolongation of tau (MEPC) from 1 ms was almost twice as great in Rann tempoiaria (tau (MEPC) = 4.4 ms) than in Rana ridibunda (tau (MEPC) = 3.1). This indicates that desensitisation reduces the number of available receptors and lowers the number of available ACh molecules for repetitive binding by trapping them by desensitised, high-affinity receptors significantly more in Rana ridibunda than in Rana temporaria. The application of proadifen, a promoter of desensitisation, decreased the prolongation of MEPCs in both species, but this shortening was more rapid in Rana ridibunda than in Rana temporaria. It is concluded that the desensitisation-induced reduction in the density, and the number of postsynaptic receptors is significantly higher at Rann ridibunda than in Rana tempo,aria endplates. (C) 2001 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 20:38:05