Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Modification of AMPA receptor clustering regulates cerebellar synaptic plasticity
Autore:
Hirai, H;
Indirizzi:
RIKEN, Brain Sci Inst, Lab Mem & Learning, Wako, Saitama 3510198, Japan RIKEN Wako Saitama Japan 3510198 & Learning, Wako, Saitama 3510198, Japan
Titolo Testata:
NEUROSCIENCE RESEARCH
fascicolo: 3, volume: 39, anno: 2001,
pagine: 261 - 267
SICI:
0168-0102(200103)39:3<261:MOARCR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM DEPRESSION; DOMAIN-CONTAINING PROTEIN; GLUTAMATE-RECEPTOR; PURKINJE-CELLS; NMDA RECEPTOR; HIPPOCAMPAL-NEURONS; INTERACTING PROTEIN; POSTSYNAPTIC DENSITY; DENDRITIC SPINES; NR1 SUBUNIT;
Keywords:
AMPA receptor; GluR2; clustering; phosphorylation; LTD; Purkinje cell; GRIP; PDZ domain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Hirai, H RIKEN, Brain Sci Inst, Lab Mem & Learning, Wako, Saitama 3510198,Japan RIKEN Wako Saitama Japan 3510198 g, Wako, Saitama 3510198, Japan
Citazione:
H. Hirai, "Modification of AMPA receptor clustering regulates cerebellar synaptic plasticity", NEUROSCI RE, 39(3), 2001, pp. 261-267

Abstract

Cerebellar long-term depression (LTD) induced at parallel fiber-Purkinje neuron synapses is proposed to underlie certain types of motor learning. alpha -Amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors, which mediate chemical transmission in these synapses, are clustered on the postsynaptic membrane. By increasing local density of the receptors, clustering is believed to increase synaptic efficacy. This article focuses on molecular mechanisms regulating the synaptic AMPA receptor clustering in Purkinje cells, which could underlie the expression of cerebellar LTD. Synaptic AMPA receptor clusters in dendritic spines of Purkinje cells are disrupted upon protein kinase C (PKC)-mediated phosphorylation of serine 880 in the C-terminal domain of GluR2. Phosphorylation of this residue causes significant reduction in the affinity of GluR2 C-terminal tail for glutamate receptor interacting protein (GRIP), a molecule known to be crucial for AMPA receptor clustering. Consequently, AMPA receptors on the synaptic membrane are destabilized and internalized by endocytosis. Based on these findings, a model for the expression of cerebellar LTD is proposed, in which a decrease in the number of postsynaptic AMPA receptors, initiated by phosphorylation of GluR2 serine 880, is the major mechanism underlying cerebellar LTD. (C) 2001 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:31:36