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Titolo:
Artificial electrotonic coupling affects neuronal firing patterns depending upon cellular characteristics
Autore:
Velazquez, JLP; Carlen, PL; Skinner, FK;
Indirizzi:
Univ Hlth Network, Toronto Western Hosp, Toronto Western Res Inst, Toronto, ON M5T 2S8, Canada Univ Hlth Network Toronto ON Canada M5T 2S8 , Toronto, ON M5T 2S8, Canada Univ Toronto, Bloorview Epilepsy Programme, Toronto, ON M5T 2S8, Canada Univ Toronto Toronto ON Canada M5T 2S8 ramme, Toronto, ON M5T 2S8, Canada Univ Toronto, Dept Med Neurol, Toronto, ON M5T 2S8, Canada Univ Toronto Toronto ON Canada M5T 2S8 eurol, Toronto, ON M5T 2S8, Canada Univ Toronto, Dept Physiol, Toronto, ON M5T 2S8, Canada Univ Toronto Toronto ON Canada M5T 2S8 ysiol, Toronto, ON M5T 2S8, Canada Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5T 2S8, Canada Univ Toronto Toronto ON Canada M5T 2S8 Engn, Toronto, ON M5T 2S8, Canada
Titolo Testata:
NEUROSCIENCE
fascicolo: 3, volume: 103, anno: 2001,
pagine: 841 - 849
SICI:
0306-4522(2001)103:3<841:AECANF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAP JUNCTION CHANNELS; FIELD BURST ACTIVITY; IN-VITRO; INTERNEURONAL NETWORKS; ELECTRICAL SYNAPSES; PYRAMIDAL CELLS; RAT HIPPOCAMPUS; FREQUENCY; MODEL; OSCILLATIONS;
Keywords:
electrotonic coupling; whole-cell recordings; thalamic neurons; pyramidal neurons;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Velazquez, JLP Univ Hlth Network, Toronto Western Hosp, Toronto Western Res Inst, McL12-413,399 Bathurst St, Toronto, ON M5T 2S8, Canada Univ Hlth Network McL12-413,399 Bathurst St Toronto ON Canada M5T 2S8
Citazione:
J.L.P. Velazquez et al., "Artificial electrotonic coupling affects neuronal firing patterns depending upon cellular characteristics", NEUROSCIENC, 103(3), 2001, pp. 841-849

Abstract

While there have been numerous theoretical studies indicating that electrotonic coupling via gap junctions interacts with the intrinsic characteristics of the coupled neurons to modify their electrical behaviour, little experimental evidence has been provided in coupled mammalian neurons. Using an artificial electrotonic junction, two distant uncoupled neurons were coupled through the computer, and the coupling conductance was varied. Tonically firing CA1 hippocampal pyramidal neurons reduced their spike firing frequency when coupled to thalamic or pyramidal cells, showing that the electricalcoupling can be considered as a low-pass filter. The strength of coupling needed to entrain spike bursts of pyramidal neurons was considerably lower than the coupling needed to synchronize two neurons with different cellularcharacteristics (thalamic and pyramidal cells). Coupling promoted burst firing in a non-bursting cell if it was coupled to a spontaneously bursting neuron. These results support modelling studies that indicate a role for gap-junctional coupling in the synchronization of neuronal firing and the expressionof low-frequency bursting. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

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Documento generato il 22/01/20 alle ore 09:24:06