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Titolo:
Prostaglandin EP3 receptor protein in serotonin and catecholamine cell groups: A double immunofluorescence study in the rat brain
Autore:
Nakamura, K; Li, YQ; Kaneko, T; Katoh, H; Negishi, M;
Indirizzi:
Kyoto Univ, Grad Sch Biostudies, Mol Neurobiol Lab, Sakyo Ku, Kyoto 6068502, Japan Kyoto Univ Kyoto Japan 6068502 obiol Lab, Sakyo Ku, Kyoto 6068502, Japan Kyoto Univ, Grad Sch Med, Dept Morphol Brain Sci, Sakyo Ku, Kyoto 6068501,Japan Kyoto Univ Kyoto Japan 6068501 Brain Sci, Sakyo Ku, Kyoto 6068501,Japan Fourth Mil Med Univ, Dept Anat, Xian 710032, Peoples R China Fourth Mil Med Univ Xian Peoples R China 710032 710032, Peoples R China Fourth Mil Med Univ, KK Leung Brain Res Ctr, Xian 710032, Peoples R China Fourth Mil Med Univ Xian Peoples R China 710032 710032, Peoples R China Kyoto Univ, Japan Sci & Technol, CREST, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 ol, CREST, Sakyo Ku, Kyoto 6068501, Japan
Titolo Testata:
NEUROSCIENCE
fascicolo: 3, volume: 103, anno: 2001,
pagine: 763 - 775
SICI:
0306-4522(2001)103:3<763:PERPIS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC PREGANGLIONIC NEURONS; DOPAMINE-BETA-HYDROXYLASE; PROSTANOID RECEPTORS; NORADRENALINE RELEASE; EP(3) SUBTYPE; SPINAL-CORD; EFFERENT CONNECTIONS; MEDULLA-OBLONGATA; NERVOUS-SYSTEM; CONSCIOUS MICE;
Keywords:
prostaglandin E-2; fluorescence immunocytochemistry; regulation of the autonomic nervous system; pain modulation; tyrosine hydroxylase; brainstem;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Nakamura, K Kyoto Univ, Grad Sch Biostudies, Mol Neurobiol Lab, Sakyo Ku, Kyoto 6068502, Japan Kyoto Univ Kyoto Japan 6068502 akyo Ku, Kyoto 6068502, Japan
Citazione:
K. Nakamura et al., "Prostaglandin EP3 receptor protein in serotonin and catecholamine cell groups: A double immunofluorescence study in the rat brain", NEUROSCIENC, 103(3), 2001, pp. 763-775

Abstract

Prostaglandin E-2 exerts diverse physiological actions in the central nervous system with unknown mechanisms. We have reported the immunohistochemical localization of the EP3 receptor, one of the prostaglandin E receptor subtypes, in various brain regions including many monoaminergic nuclei. In thepresent study, a double immunofluorescence technique with an antibody to EP3 receptor and antibodies to markers for monoamine neurons was employed toexamine the expression of the receptor in serotonin and catecholamine neurons, and to reveal the distribution of the receptor-expressing monoamine neurons in the rat brain. Almost all serotonergic cells in the medulla oblongata (B1-B4) exhibited EP3 receptorlike immunoreactivity, whereas mesencephalic and pontine serotonergic cell groups (B5-B9) contained relatively smallpopulations of EP3 receptor-immunoreactive cells. In the catecholaminergiccell groups, many of the noradrenergic A7 cells in the subcoeruleus nucleus showed immunoreactivity for the receptor. The locus coeruleus exhibited EP3 receptor-like immunoreactivity densely in the neuropil and occasionally in neuronal cell bodies, all of which were immunopositive for dopamine beta-hydroxylase, as observed by confocal laser microscopy. Many of the other noradrenergic and adrenergic cell groups contained small populations of EP3receptor-like immunoreactive cells. In contrast, no EP3 receptor-like immuno reactivity was detected in the noradrenergic A2 and A4, the adrenergic C2, and all the dopaminergic cell groups. The expression of EP3 receptor by most of the serotonergic, noradrenergic and adrenergic cell groups suggests that prostaglandin E2 modulates many physiological processes mediated by widely distributed monoaminergic projections through activation of the EP3 receptor on the monoaminergic neurons; for instance, it may modulate nociceptive and autonomic processes by affecting the descending serotonergic pathway from the raphe magnus nucleus to the spinal cord. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 00:59:27