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Titolo:
Parafascicular thalamic nucleus deafferentation reduces c-fos expression induced by dopamine D-l receptor stimulation in rat striatum
Autore:
Giorgi, S; Rimoldi, M; Consolo, S;
Indirizzi:
Ist Ric Farmacol Mario Negri, I-20157 Milan, Italy Ist Ric Farmacol Mario Negri Milan Italy I-20157 i, I-20157 Milan, Italy
Titolo Testata:
NEUROSCIENCE
fascicolo: 3, volume: 103, anno: 2001,
pagine: 653 - 661
SICI:
0306-4522(2001)103:3<653:PTNDRC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIVO ACETYLCHOLINE-RELEASE; TRANSCRIPTION FACTOR CREB; MESSENGER-RNA EXPRESSION; GENE-EXPRESSION; IN-VIVO; AGONIST SKF-82958; NERVOUS-SYSTEM; INDUCTION; AMPHETAMINE; NEURONS;
Keywords:
northern blot; in situ hybridization; electrolytic lesion; SKF-82958;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Consolo, S Ist Ric Farmacol Mario Negri, Viale Eritrea 62, I-20157 Milan, Italy Ist Ric Farmacol Mario Negri Viale Eritrea 62 Milan Italy I-20157
Citazione:
S. Giorgi et al., "Parafascicular thalamic nucleus deafferentation reduces c-fos expression induced by dopamine D-l receptor stimulation in rat striatum", NEUROSCIENC, 103(3), 2001, pp. 653-661

Abstract

We investigated the role played by the parafascicular thalamostriatal pathway, one of the major excitatory inputs to the striatum, in the D-l receptor induction of c-fos messenger RNA expression in the rat striatum. The fullD-l receptor agonist, SKF-82958 (0.05, 0.1, 0.5 and 1 mg/kg, s.c., 30 min), dose-dependently induced c-Sos messenger RNA in naive rat striatum as determined by northern blot analysis. One day following electrolytic lesion ofthe parafascicular thalamostriatal nucleus, striatal c-fos signal by itself was not altered but the stimulated expression of c-fos was strongly decreased. Sections of sham-operated and acute-lesioned dorsal striata of vehicle- or SKF-82958-treated rats were processed for in situ hybridization histochemistry at the single-cell level with an RNA probe for c-fos. The basal expression of striatal c-fos was poorly detectable in sham and lesioned groups. Sections of dorsal striata from sham-operated rats treated with SKF-82958 showed two types of labeled neurons for c-fos: the lightly and the very densely labeled neurons which are few in number. Thalamic lesion strongly reduced SKF-82958 stimulated expression of c-fos RNA in both types of labeled cells. The frequency distribution of c-Sos labeling per neuron in dorsal striata of lesioned rats treated with SKF-82958 was shifted to the left, and its median was lower than in the sham-operated striata treated with the D-l receptor agonist. The results provide evidence that the excitatory projections from the parafascicular nucleus of the thalamus, thought to operate primarily through the N-methyl-D-aspartate receptors, exert a facilitatory control over D-l receptor-induced c-fos gene expression specifically in the dorsal striatum. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 06:53:57