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Titolo:
Glucocorticoid receptors and serotonin N-acetyltransferase activity in thefish pineal organ
Autore:
Benyassi, A; Schwartz, C; Ducouret, B; Falcon, J;
Indirizzi:
Univ Paris 06, Lab Arago, Observ Oceanol, CNRS,UMR 7628, Banyuls sur Mer, France Univ Paris 06 Banyuls sur Mer France ,UMR 7628, Banyuls sur Mer, France Fac Sci Fes, Physiol Anim Lab, Fes, Morocco Fac Sci Fes Fes MoroccoFac Sci Fes, Physiol Anim Lab, Fes, Morocco NICHHD, Dev Neurobiol Lab, NIH, Bethesda, MD 20892 USA NICHHD Bethesda MDUSA 20892 v Neurobiol Lab, NIH, Bethesda, MD 20892 USA Inst Biol & Ecol Poissons Rennes, CNRS, UPRESA 6026, Rennes, France Inst Biol & Ecol Poissons Rennes Rennes France ESA 6026, Rennes, France
Titolo Testata:
NEUROREPORT
fascicolo: 5, volume: 12, anno: 2001,
pagine: 889 - 892
SICI:
0959-4965(20010417)12:5<889:GRASNA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARTIAL AGONIST ACTIVITY; CORTISOL-LEVELS; MELATONIN PRODUCTION; GENE-EXPRESSION; ATLANTIC SALMON; CELLS; MIFEPRISTONE; PHOTOPERIOD; ESTROGENS; GOLDFISH;
Keywords:
arylalkylamine N-acetyltransferase; dexamethasone; fish; glucocorticoid receptors; melatonin; pineal organ; RU486;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Falcon, J Univ Paris 06, Lab Arago, Observ Oceanol, CNRS,UMR 7628, BP 44, Banyuls sur Mer, France Univ Paris 06 BP 44 Banyuls sur Mer France uls sur Mer, France
Citazione:
A. Benyassi et al., "Glucocorticoid receptors and serotonin N-acetyltransferase activity in thefish pineal organ", NEUROREPORT, 12(5), 2001, pp. 889-892

Abstract

This study aimed to determine whether glucocorticoid receptors are expressed in the photosensitive trout pineal organ, and whether glucocorticoids modulate melatonin secretion. On Western blots from pineal extracts, an antibody directed against trout glucocorticoid receptor labeled a single band atthe expected size (similar to 100 kDa). Dexamethasone inhibited pineal arylalkylamine N-acetyltransferase activity (AANAT2; serotonin --> N-acetylserotonin) in a dose-dependent manner after 6 h of culture in the dark (IC50 2.10(-8)M). RU486 (10(-7) M ) alone had a partial agonistic activity, whereas it antagonized the effects of 10(-8) M dexamethasone. Hydroxyindole-O-methyltransferase activity (N-acetylserotonin --> melatonin) remained unaffected. This is the first demonstration that glucocorticoid receptors are present in the pineal organ and that glucocorticoids modulate melatonin production. Neuro-Report 12:889-892 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 14:52:20