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Titolo:
Increased risk for frontotemporal dementia through interaction between taupolymorphisms and apolipoprotein E epsilon 4
Autore:
Ingelson, M; Fabre, SF; Lilius, L; Andersen, C; Viitanen, M; Almkvist, O; Wahlund, LO; Lannfelt, L;
Indirizzi:
Karolinska Inst, Novum, NEUROTEC, KFC, S-14186 Huddinge, Sweden KarolinskaInst Huddinge Sweden S-14186 C, KFC, S-14186 Huddinge, Sweden
Titolo Testata:
NEUROREPORT
fascicolo: 5, volume: 12, anno: 2001,
pagine: 905 - 909
SICI:
0959-4965(20010417)12:5<905:IRFFDT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; FRONTAL-LOBE DEGENERATION; NON-ALZHEIMER TYPE; GENETIC-EVIDENCE; DISEASE; ASSOCIATION; INVOLVEMENT; ALLELE; MICE;
Keywords:
apoE; frontotemporal dementia; polymorphisms; tau;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Lannfelt, L Karolinska Inst, Novum, NEUROTEC, KFC, S-14186 Huddinge, Sweden Karolinska Inst Huddinge Sweden S-14186 186 Huddinge, Sweden
Citazione:
M. Ingelson et al., "Increased risk for frontotemporal dementia through interaction between taupolymorphisms and apolipoprotein E epsilon 4", NEUROREPORT, 12(5), 2001, pp. 905-909

Abstract

The tau gene has an important role in frontotemporal dementia (FTD) as pathogenic mutations have been found in hereditary forms of the disease. Furthermore, a certain extended tau haplotype has been shown to increase the risk for progressive supranuclear palsy, corticobasal degeneration, Parkinson's disease and, in interaction with the apolipoprotein E (apoE) epsilon4 allele, Alzheimer's disease. By microsatellite analysis we investigated an intronic tau polymorphism, in linkage disequilibrium with the extended tau haplotype, in FTD patients (n = 36) and healthy controls (n = 39). No association between any of the tau alleles/genotypes and FTD was seen, but certain tau alleles and apoE epsilon4 interactively increased the risk of FTD (p = 0.006). We thus propose that this extended tau haplotype in combination with apoE epsilon4 is a genetic risk factor for FTD. NeuroReport 12:905-909 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:32:51