Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Intracellular processing of aggregated tan differs between corticobasal degeneration and progressive supranuclear palsy
Autore:
Arai, T; Ikeda, K; Akiyama, H; Tsuchiya, K; Yagishita, S; Takamatsu, J;
Indirizzi:
Tokyo Inst Psychiat, Dept Neuropathol, Setagaya Ku, Tokyo 1568585, Japan Tokyo Inst Psychiat Tokyo Japan 1568585 etagaya Ku, Tokyo 1568585, Japan Tokyo Metropolitan Matsuzawa Hosp, Setagaya Ku, Tokyo 1560057, Japan TokyoMetropolitan Matsuzawa Hosp Tokyo Japan 1560057 kyo 1560057, Japan Kanagawa Rehabil Ctr, Div Pathol, Atsugi, Kanagawa 24301, Japan Kanagawa Rehabil Ctr Atsugi Kanagawa Japan 24301 i, Kanagawa 24301, Japan Kikuchi Natl Hosp, Div Clin Res, Kumamoto 86111, Japan Kikuchi Natl Hosp Kumamoto Japan 86111 v Clin Res, Kumamoto 86111, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 5, volume: 12, anno: 2001,
pagine: 935 - 938
SICI:
0959-4965(20010417)12:5<935:IPOATD>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAIRED HELICAL FILAMENTS; ALZHEIMERS-DISEASE; TANGLES; PROTEOLYSIS; CALPAIN;
Keywords:
immunoblot; proteolysis; aggregate; fragment; isoform;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Arai, T Tokyo Inst Psychiat, Dept Neuropathol, Setagaya Ku, 2-1-8 Kamikitazawa, Tokyo 1568585, Japan Tokyo Inst Psychiat 2-1-8 Kamikitazawa Tokyo Japan 1568585 Japan
Citazione:
T. Arai et al., "Intracellular processing of aggregated tan differs between corticobasal degeneration and progressive supranuclear palsy", NEUROREPORT, 12(5), 2001, pp. 935-938

Abstract

Corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) are sporadic neurodegenerative diseases with intracytoplasmic aggregates of the microtubule-associated protein, tau, in neurons and glial cells. Immunoblot analysis of detergent-insoluble brain extracts of patients with CBD and PSP shows distinctive patterns of tau fragments. These results suggest differing intracellular processing of aggregated tau in these two diseases despite an identical composition of tau isoforms. Such biochemical differences may be related to the neuropathological features of these diseases. NeuroReport 12:935-938 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:14:05