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Titolo:
Localization of neurotensin NTS2 receptors in rat brain, using [H-3]levocabastine
Autore:
Asselin, ML; Dubuc, I; Coquerel, A; Costentin, J;
Indirizzi:
Fac Med & Pharm Rouen, IFRMP 23, Unite Neuropsychopharmacol Expt, CNRS,UMR6036, F-76183 Rouen, France Fac Med & Pharm Rouen Rouen France F-76183 MR6036, F-76183 Rouen, France CHU Cote Nacre, Pharmacol Lab, F-14033 Caen, France CHU Cote Nacre Caen France F-14033 , Pharmacol Lab, F-14033 Caen, France
Titolo Testata:
NEUROREPORT
fascicolo: 5, volume: 12, anno: 2001,
pagine: 1087 - 1091
SICI:
0959-4965(20010417)12:5<1087:LONNRI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-PROPERTIES; FUNCTIONAL EXPRESSION; LEVOCABASTINE; AGONIST; SITES; PEPTIDE; CLONING; TISSUE;
Keywords:
autoradiography; [H-3]levocabastine; NTS2 receptors; rat brain;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Costentin, J Fac Med & Pharm Rouen, IFRMP 23, Unite Neuropsychopharmacol Expt, CNRS,UMR6036, 22 Bd Gambetta, F-76183 Rouen, France Fac Med & Pharm Rouen 22 Bd Gambetta Rouen France F-76183 ce
Citazione:
M.L. Asselin et al., "Localization of neurotensin NTS2 receptors in rat brain, using [H-3]levocabastine", NEUROREPORT, 12(5), 2001, pp. 1087-1091

Abstract

The brain localization of the neurotensin receptor NTS2 was studied with [H-3]levocabastine, using an autoradiographic procedure. This study suggeststhat NTS2 receptors are mainly intracellular. High densities of binding sites were observed in the cingulate, insular, temporal, occipital, enthorhinal cortex, amygdaloid complex, septohippocampal nuclei, medial thalamus, mammillary bodies and superior colliculi; a moderate labelling was observed in the anterior and medial hippocampus, olfactory tubercle, hypothalamus, periaqueductal gray matter, caudate putamen, nucleus accumbens, septum, lateral thalamus, dorsal raphe nucleus and cerebellum; finally, a low labelling was apparent in the ventral tegmentum area and substantia nigra. Thus it appears that NTS2 receptors are particularly abundant in the cerebral cortex,the limbic areas and some areas involved in pain perception. NeuroReport 12:1087-1091 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:48:18