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Titolo:
Analysis of effects and pharmacokinetics of subcutaneously administered BDNF
Autore:
Kishino, A; Katayama, N; Ishige, Y; Yamamoto, Y; Ogo, H; Tatsuno, T; Mine, T; Noguchi, H; Nakayama, C;
Indirizzi:
Sumitomo Pharmaceut Co Ltd, Div Res, Konohana Ku, Osaka 5540022, Japan Sumitomo Pharmaceut Co Ltd Osaka Japan 5540022 Ku, Osaka 5540022, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 5, volume: 12, anno: 2001,
pagine: 1067 - 1072
SICI:
0959-4965(20010417)12:5<1067:AOEAPO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINAL MOTOR-NEURONS; TRKB MESSENGER-RNA; NEUROTROPHIC FACTOR; NERVOUS-SYSTEM; GROWTH-FACTOR; CELL-DEATH; BRAIN; MOTONEURONS; RECEPTORS; RAT;
Keywords:
axotomy; BDNF; facial nerve; pharmacokinetics; sciatic nerve;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Nakayama, C Sumitomo Pharmaceut Co Ltd, Div Res, Konohana Ku, 3-1-98 Kasugadenaka, Osaka 5540022, Japan Sumitomo Pharmaceut Co Ltd 3-1-98 Kasugadenaka Osaka Japan 5540022
Citazione:
A. Kishino et al., "Analysis of effects and pharmacokinetics of subcutaneously administered BDNF", NEUROREPORT, 12(5), 2001, pp. 1067-1072

Abstract

Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family and has been shown to be a potent and effective trophic factor for motor neurons and other neurons of the peripheral and central nervous. Little is known, however, about the relationship between the efficacy and pharmacokinetics of s.c. administered BDNF. In this study, the efficacy of BDNF on motor neuron protection in sciatic or facial nerve axotomy models was examinedand compared with the concommitant concentrations of BDNF in plasma. Delayed treatment (started at I week after surgery) of BDNF was also shown to retard choline acetyltransferase reduction in sciatic nerve axotomy models. NeuroReport 12:1067-1072 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:09:37