Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Increased expression of synaptophysin and stathmin mRNAs after methamphetamine administration in rat brain
Autore:
Takaki, M; Ujike, H; Kodama, M; Takehisa, Y; Yamamoto, A; Kuroda, S;
Indirizzi:
Okayama Univ, Sch Med, Dept Neuropsychiat, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 Neuropsychiat, Okayama 7008558, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 5, volume: 12, anno: 2001,
pagine: 1055 - 1060
SICI:
0959-4965(20010417)12:5<1055:IEOSAS>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED BEHAVIORAL SENSITIZATION; REPEATED AMPHETAMINE; DOPAMINE RELEASE; MESSENGER-RNAS; PHOSPHORYLATION; NEUROMODULIN; STRIATUM; PROTEINS; SYNAPSIN; TUBULIN;
Keywords:
behavioral sensitization; in situ hybridization; methamphetamine; neural plasticity; stathmin; synaptophysin; alpha-tubulin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Ujike, H Okayama Univ, Sch Med, Dept Neuropsychiat, 2-5-1 Shikata Cho, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008558 8558, Japan
Citazione:
M. Takaki et al., "Increased expression of synaptophysin and stathmin mRNAs after methamphetamine administration in rat brain", NEUROREPORT, 12(5), 2001, pp. 1055-1060

Abstract

The rearrangement of neural networks associated with the behavioral sensitization induced by psychostimulants is poorly understood. We have investigated the effect of methamphetamine (METH) administration on the mRNA levels of three different classes of plasticity-related genes in the rat brain. The expression of synaptophysin mRNA increased 20-40% in the nucleus accumbens, prefrontal and temporal cortices, 1-24 h after acute METH administration, and that of stathmin mRNA increased about 20% in the prefrontal cortex 1 h later. They did not change after subchronic administration. The level of alpha -tubulin mRNA was constant. Therefore, synaptophysin and stathmin play an important role in the neural plastic changes involved in the early induction process of METH-induced sensitization, but not in the later maintenance process. NeuroReport 12: 1055-1060 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:20:35