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Titolo:
Adenosine A(2A) receptor knockout mice are partially protected against drug-induced catalepsy
Autore:
El Yacoubi, M; Ledent, C; Parmentier, M; Costentin, J; Vaugeois, JM;
Indirizzi:
UFR Med & Pharm, IFRMP 23, CNRS, UMR 6036, F-76183 Rouen, France UFR Med &Pharm Rouen France F-76183 RS, UMR 6036, F-76183 Rouen, France Free Univ Brussels, IRIBHN, B-1070 Brussels, Belgium Free Univ Brussels Brussels Belgium B-1070 BHN, B-1070 Brussels, Belgium
Titolo Testata:
NEUROREPORT
fascicolo: 5, volume: 12, anno: 2001,
pagine: 983 - 986
SICI:
0959-4965(20010417)12:5<983:AARKMA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HALOPERIDOL-INDUCED CATALEPSY; PARKINSONS-DISEASE; ANTAGONISTS; EXPRESSION;
Keywords:
adenosine A(2A) receptor; catalepsy; haloperidol; knockout mice; pilocarpine; SCH 23390;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Vaugeois, JM UFR Med & Pharm, IFRMP 23, CNRS, UMR 6036, 22 Blvd Gambetta, F-76183 Rouen, France UFR Med & Pharm 22 Blvd Gambetta Rouen France F-76183 France
Citazione:
M. El Yacoubi et al., "Adenosine A(2A) receptor knockout mice are partially protected against drug-induced catalepsy", NEUROREPORT, 12(5), 2001, pp. 983-986

Abstract

Catalepsy assessed using the bar test was measured in both adenosine A(2A)receptor knockout (A(2A)R KO) and wild-type (A(2A)R WT) mice submitted to acute administration of the dopamine D-2 receptor antagonist haloperidol (0.5, 2, 4, 6 mg/kg i.p.), the dopamine D-1 antagonist SCH 23390 (0.3-3 mg/kg, s.c.), the vesicular monoamine transporter blocker reserpine (3-5 mg/kg, s.c.) or the acetylcholine muscarinic receptor agonist pilocarpine (25-50 mg/kg, i.p.). Except for reserpine, catalepsy scores were significantly lower in A(2A)R KO mice than in A(2A)R WT mice following low doses of these cataleptogenic agents. These results suggest that adenosine A(2A) receptors influence not only dopamine D-2 and D-1 receptor-mediated neurotransmission but also acetylcholine muscarinic receptor-mediated neurotransmission. NeuroReport 12:983-986 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:06:40