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Titolo:
Differential effects of lovastatin treatment on brain cholesterol levels in normal and ApoE-deficient mice
Autore:
Eckert, GP; Kirsch, C; Mueller, WE;
Indirizzi:
Univ Frankfurt, Bioctr Niederursel, Dept Pharmacol, D-60439 Frankfurt, Germany Univ Frankfurt Frankfurt Germany D-60439 col, D-60439 Frankfurt, Germany
Titolo Testata:
NEUROREPORT
fascicolo: 5, volume: 12, anno: 2001,
pagine: 883 - 887
SICI:
0959-4965(20010417)12:5<883:DEOLTO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN-E; ALZHEIMERS-DISEASE; REDUCTASE INHIBITORS; IN-VITRO; TRANSPORT; HIPPOCAMPUS; PATHOLOGY; MOUSE; VIVO;
Keywords:
ApoE-deficient mice; brain cholesterol; lovastatin treatment;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Mueller, WE Univ Frankfurt, Bioctr Niederursel, Dept Pharmacol, Marie Curie Str 9, D-60439 Frankfurt, Germany Univ Frankfurt Marie Curie Str 9 Frankfurt Germany D-60439 ny
Citazione:
G.P. Eckert et al., "Differential effects of lovastatin treatment on brain cholesterol levels in normal and ApoE-deficient mice", NEUROREPORT, 12(5), 2001, pp. 883-887

Abstract

Growing evidence indicates that membrane cholesterol is involved in the development of Alzheimer's disease. Therefore, the availability of pharmacological strategies to modify brain cholesterol is of increasing importance. Accordingly, we investigated the effects of the HMG-CoA reductase inhibitor lovastatin on brain cholesterol levels in vivo. Brain cholesterol was significantly decreased by lovastatin treatment (100 mg/kg/day) in 1- and 12-month-old C57BL/6J mice. Reduced brain cholesterol was associated with decreased pyrene-excimer fluorescence, indicating altered membrane function. Lovastatin had no effect on brain cholesterol in ApoE-/- mice. Peripheral cholesterol levels were not affected by lovastatin in all three groups of mice. We demonstrate for the first time that lovastatin represents a valid pharmacological tool to significantly modulate brain cholesterol levels. NeuroReport 12:883-887 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 08:57:07