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Titolo:
Melatonin delays photoreceptor degeneration in the rds/rds mouse
Autore:
Liang, FQ; Aleman, TS; Yang, ZX; Cideciyan, AV; Jacobson, SG; Bennett, J;
Indirizzi:
Univ Penn, Sch Med, Scheie Eye Inst, Dept Ophthalmol,Stellar Chance Labs 310, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Labs 310, Philadelphia, PA 19104 USA
Titolo Testata:
NEUROREPORT
fascicolo: 5, volume: 12, anno: 2001,
pagine: 1011 - 1014
SICI:
0959-4965(20010417)12:5<1011:MDPDIT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINITIS-PIGMENTOSA; CELL-DEATH; DAMAGE; KAINATE; APOPTOSIS; COUNTERACTS; PROTECTION; ISCHEMIA; RATS;
Keywords:
apoptosis; melatonin; photoreceptor; retina; retinal degeneration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Bennett, J Univ Penn, Sch Med, Scheie Eye Inst, Dept Ophthalmol,Stellar Chance Labs 310, 422 Curie Blvd, Philadelphia, PA 19104 USA Univ Penn 422 Curie Blvd Philadelphia PA USA 19104 PA 19104 USA
Citazione:
F.Q. Liang et al., "Melatonin delays photoreceptor degeneration in the rds/rds mouse", NEUROREPORT, 12(5), 2001, pp. 1011-1014

Abstract

Photoreceptors in retinitis pigmentosa (RP), a group of inherited retinal degenerative diseases, die through apoptosis. Since melatonin protects against neuronal apoptotic death, we tested its ability to slow photoreceptor degeneration in the rds/rds mouse, an animal model for RP. Shortly after birth, rds/ rds mice were given daily i.p. injections of melatonin or vehicle for 11 weeks. Melatonin treatment significantly delayed photoreceptor loss and reduced the number of apoptotic photoreceptors. Further studies should determine if melatonin will have potential for the treatment of certain human retinal degenerations. NeuroReport 12:1011-1014 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 17:15:13