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Titolo:
Insulin inhibits voltage-dependent calcium influx into rod photoreceptors
Autore:
Stella, SL; Bryson, EJ; Thoreson, WB;
Indirizzi:
Univ Nebraska, Med Ctr, Dept Pharmacol, Omaha, NE 68198 USA Univ NebraskaOmaha NE USA 68198 Ctr, Dept Pharmacol, Omaha, NE 68198 USA Univ Nebraska, Med Ctr, Dept Ophthalmol, Omaha, NE 68198 USA Univ Nebraska Omaha NE USA 68198 tr, Dept Ophthalmol, Omaha, NE 68198 USA
Titolo Testata:
NEUROREPORT
fascicolo: 5, volume: 12, anno: 2001,
pagine: 947 - 951
SICI:
0959-4965(20010417)12:5<947:IIVCII>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; RECEPTOR; CHANNEL; RETINA; CA2+; ELECTRORETINOGRAM; CURRENTS; PROTEIN; MOUSE; CELLS;
Keywords:
calcium channel; calcium imaging; fura-2; HNMPA-(AM)(3); insulin; lavendustin A and B; retinal slice; rod; tyrosine kinase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Thoreson, WB Univ Nebraska, Med Ctr, Dept Pharmacol, 600 S 42nd St, Omaha,NE 68198 USA Univ Nebraska 600 S 42nd St Omaha NE USA 68198 , NE 68198 USA
Citazione:
S.L. Stella et al., "Insulin inhibits voltage-dependent calcium influx into rod photoreceptors", NEUROREPORT, 12(5), 2001, pp. 947-951

Abstract

Insulin inhibits the ERG b-wave and modulates L-type calcium currents (I-Ca) in various preparations. We therefore examined insulin's effects on l(Ca) and depolarization-evoked [Ca2+](i) increases in rod photoreceptors. Insulin inhibited I-Ca and caused a dose-dependent reduction in the depolarization-evoked Ca2+ influx with an EC50 of 2.1 nM. Tyrosine kinase inhibitors, lavendustin A (100 nM) and genistein (10 muM), prevented insulin from reducing the depolarization-evoked Ca2+ increase in rods. Their less active analogues, lavendustin B and daidzein, had similar effects. An insulin receptor-specific tyrosine kinase inhibitor, HNMPA-(AM)(3) (50 muM), prevented insulin (30 nM) from reducing the depolarization-evoked Ca2+ increase in rods. The results suggest that insulin inhibits Ca2+ influx through voltage-dependent I-Ca in rod photoreceptors via tyrosine kinase activity. NeuroReport 12:947-951 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 18/01/20 alle ore 13:02:47