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Titolo:
Impact of active dendrites and structural plasticity on the memory capacity of neural tissue
Autore:
Poirazi, P; Mel, BW;
Indirizzi:
Univ So Calif, Dept Biomed Engn, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 ed Engn, Los Angeles, CA 90089 USA
Titolo Testata:
NEURON
fascicolo: 3, volume: 29, anno: 2001,
pagine: 779 - 796
SICI:
0896-6273(200103)29:3<779:IOADAS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEOCORTICAL PYRAMIDAL NEURONS; EXCITATORY POSTSYNAPTIC POTENTIALS; CALCIUM ACTION-POTENTIALS; LONG-TERM POTENTIATION; CAT STRIATE CORTEX; RAT BARREL CORTEX; HIPPOCAMPAL-NEURONS; APICAL DENDRITES; MACAQUE MONKEY; VISUAL-CORTEX;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
108
Recensione:
Indirizzi per estratti:
Indirizzo: Poirazi, P Univ So Calif, Dept Biomed Engn, Los Angeles, CA 90089 USA UnivSo Calif Los Angeles CA USA 90089 s Angeles, CA 90089 USA
Citazione:
P. Poirazi e B.W. Mel, "Impact of active dendrites and structural plasticity on the memory capacity of neural tissue", NEURON, 29(3), 2001, pp. 779-796

Abstract

We consider the combined effects of active dendrites and structural plasticity on the storage capacity of neural tissue. We compare capacity for two different modes of dendritic integration: (1) linear, where synaptic inputsare summed across the entire dendritic arbor, and (2) nonlinear, where each dendritic compartment functions as a separately thresholded neuron-like summing unit. We calculate much larger storage capacities for cells with nonlinear subunits and show that this capacity is accessible to a structural learning rule that combines random synapse formation with activity-dependentstabilization/elimination. In a departure from the common view that memories are encoded in the overall connection strengths between neurons, our results suggest that long-term information storage in neural tissue could reside primarily in the selective addressing of synaptic contacts onto dendritic subunits.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:02:05