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Titolo:
Monosynaptic GABAergic signaling from dentate to CA3 with a pharmacological and physiological profile typical of mossy fiber synapses
Autore:
Walker, MC; Ruiz, A; Kullmann, DM;
Indirizzi:
Univ Coll London, Inst Neurol, Dept Clin Neurol, London WC1N 3BG, England Univ Coll London London England WC1N 3BG eurol, London WC1N 3BG, England
Titolo Testata:
NEURON
fascicolo: 3, volume: 29, anno: 2001,
pagine: 703 - 715
SICI:
0896-6273(200103)29:3<703:MGSFDT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; METABOTROPIC GLUTAMATE RECEPTORS; EXCITATORY GRANULE CELLS; TEMPORAL-LOBE EPILEPSY; RAT HIPPOCAMPUS; GUINEA-PIG; HETEROSYNAPTIC DEPRESSION; NEURONS; GABA; ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Kullmann, DM Univ Coll London, Inst Neurol, Dept Clin Neurol, Queen Sq, London WC1N 3BG, England Univ Coll London Queen Sq London England WC1N 3BG G, England
Citazione:
M.C. Walker et al., "Monosynaptic GABAergic signaling from dentate to CA3 with a pharmacological and physiological profile typical of mossy fiber synapses", NEURON, 29(3), 2001, pp. 703-715

Abstract

Mossy fibers are the sole excitatory projection from dentate gyrus granulecells to the hippocampus, where they release glutamate, dynorphin, and zinc. In addition, mossy fiber terminals show intense immunoreactivity for theinhibitory neurotransmitter GABA. Fast inhibitory transmission at mossy fiber synapses, however, has not previously been reported. Here, we show thatelectrical or chemical stimuli that recruit dentate granule cells elicit monosynaptic GABA, receptor-mediated synaptic signals in CA3 pyramidal neurons. These inhibitory signals satisfy the criteria that distinguish mossy fiber-CA3 synapses: high sensitivity to metabotropic glutamate receptor agonists, facilitation during repetitive stimulation, and NMDA receptor-independent long-term potentiation. GABAergic transmission from the dentate gyrus to CA3 has major implications not only for information flow into the hippocampus but also for developmental and pathological processes involving the hippocampus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:22:14