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Titolo:
Pair recordings reveal all-silent synaptic connections and the postsynaptic expression of long-term potentiation
Autore:
Montgomery, JM; Pavlidis, P; Madison, DV;
Indirizzi:
Stanford Univ, Sch Med, Dept Cellular & Mol Physiol, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 & Mol Physiol, Stanford, CA 94305 USA
Titolo Testata:
NEURON
fascicolo: 3, volume: 29, anno: 2001,
pagine: 691 - 701
SICI:
0896-6273(200103)29:3<691:PRRASC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRASYNAPTIC GLUTAMATE SPILLOVER; HIPPOCAMPAL SLICE CULTURES; CA3 PYRAMIDAL CELLS; RAT HIPPOCAMPUS; TRANSPORTER CURRENTS; AMPA RECEPTORS; SYNAPSES; LTP; RELEASE; NEURONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Madison, DV Stanford Univ, Sch Med, Dept Cellular & Mol Physiol, Stanford,CA 94305 USA Stanford Univ Stanford CA USA 94305 l, Stanford, CA 94305 USA
Citazione:
J.M. Montgomery et al., "Pair recordings reveal all-silent synaptic connections and the postsynaptic expression of long-term potentiation", NEURON, 29(3), 2001, pp. 691-701

Abstract

The activation of silent synapses is a proposed mechanism to account for rapid increases in synaptic efficacy such as long-term potentiation (LTP). Using simultaneous recordings from individual pre- and postsynaptic neurons in organotypic hippocampal slices, we show that two CA3 neurons can be connected entirely by silent synapses. Increasing release probability or application of cyclothiazide does not produce responses from these silent synapses. Direct measurement of NMDAR-mediated postsynaptic responses in all-silent synaptic connections before and after LTP induction show no change in failure rate, amplitude. or area. These data do not support hypotheses that synapse silent results from presynaptic factors or that LTP results from increases in presynaptic glutamate release. LTP is also associated with an increase in postsynaptic responsiveness to exogenous AMPA. We conclude that synapse silence, activation, and expression of LTP are postsynaptic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 15:32:27