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Titolo:
TRPC1 and TRPC5 form a novel cation channel in mammalian brain
Autore:
Strubing, C; Krapivinsky, G; Krapivinsky, L; Clapham, DE;
Indirizzi:
Harvard Univ, Sch Med, Childrens Hosp, Howard Hughes Med Inst,Dept Neurobiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 nst,Dept Neurobiol, Boston, MA 02115 USA
Titolo Testata:
NEURON
fascicolo: 3, volume: 29, anno: 2001,
pagine: 645 - 655
SICI:
0896-6273(200103)29:3<645:TATFAN>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPACITATIVE CA2+ ENTRY; LIGHT-SENSITIVE CHANNELS; DROSOPHILA TRP; GLUTAMATE-RECEPTORS; MOLECULAR-CLONING; STORE DEPLETION; FUNCTIONAL-CHARACTERIZATION; CALMODULIN REGULATION; ENDOTHELIAL-CELLS; INSP(3) RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Clapham, DE Harvard Univ, Sch Med, Childrens Hosp, Howard Hughes Med Inst,Dept Neurobiol, 320 Longwood Ave, Boston, MA 02115 USA Harvard Univ 320 Longwood Ave Boston MA USA 02115 MA 02115 USA
Citazione:
C. Strubing et al., "TRPC1 and TRPC5 form a novel cation channel in mammalian brain", NEURON, 29(3), 2001, pp. 645-655

Abstract

TRP proteins are cation channels responding to receptor-dependent activation of phospholipase C. Mammalian (TRPC) channels can form hetero-oligomericchannels in vitro, but native TRPC channel complexes have not been identified to date. We demonstrate here that TRPC1 and TRPC5 are subunits of a heteromeric neuronal channel. Both TRPC proteins have overlapping distributions in the hippocampus. Coexpression of TRPC1 and TRPC5 in HEK293 cells resulted in a novel nonselective cation channel with a voltage dependence similar to NMDA receptor channels, but unlike that of any reported TRPC channel. TRPC1/TRPC5 heteromers were activated by G(q)-coupled receptors but not by depletion of intracellular Ca2+ stores. In contrast to the more common viewof the TRP family as comprising store-operated channels, we propose that many TRPC heteromers form diverse receptor-regulated nonselective cation channels in the mammalian brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:18:08