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Titolo:
Severe anterograde amnesia with extensive hippocampal degeneration in a case of rapidly progressive frontotemporal dementia
Autore:
Caine, D; Patterson, K; Hodges, JR; Heard, R; Halliday, G;
Indirizzi:
Addenbrookes Hosp, Univ Dept Neurol, Cambridge, England Addenbrookes HospCambridge England niv Dept Neurol, Cambridge, England MRC, Cognit & Brain Sci Unit, Cambridge, England MRC Cambridge EnglandMRC, Cognit & Brain Sci Unit, Cambridge, England Westmead Hosp, Westmead, NSW 2145, Australia Westmead Hosp Westmead NSW Australia 2145 , Westmead, NSW 2145, Australia Prince Wales Med Res Inst, Sydney, NSW, Australia Prince Wales Med Res Inst Sydney NSW Australia t, Sydney, NSW, Australia
Titolo Testata:
NEUROCASE
fascicolo: 1, volume: 7, anno: 2001,
pagine: 57 - 64
SICI:
1355-4794(2001)7:1<57:SAAWEH>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRONTAL-LOBE DEGENERATION; NON-ALZHEIMER TYPE; SEMANTIC DEMENTIA; FLUENT APHASIA; DISEASE; MEMORY; CRITERIA; ATROPHY; FEATURES; CONSENSUS;
Keywords:
frontotemporal dementia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Caine, D Univ Sydney, Dept Psychol, Sydney, NSW 2006, Australia Univ Sydney Sydney NSW Australia 2006 ydney, NSW 2006, Australia
Citazione:
D. Caine et al., "Severe anterograde amnesia with extensive hippocampal degeneration in a case of rapidly progressive frontotemporal dementia", NEUROCASE, 7(1), 2001, pp. 57-64

Abstract

Frontotemporal dementia (FTD) is usually characterized as a spectrum of relatively slowly progressive disorders with largely focal frontal or temporal presentations. The development of clinical and research criteria for discriminating FTD from Alzheimer's disease has relied, in part, on the relative preservation of episodic memory in FTD, We present a patient with FTD who, in addition to the more typical behavioural and language deficits, had a profound anterograde amnesia at the time of diagnosis. Neuroimaging confirmed atrophy of frontal and temporal lobes bilaterally, most marked in the anterior left temporal region. At post-mortem, non-Alzheimer pathology resulting in devastating cell loss was revealed in the hippocampi, as well as in the frontal and temporal cortex, thus providing neuroanatomical corroboration of the episodic memory deficit. Progression of the disease was extraordinarily rapid, with just 2 years between reported onset and time of death. This case demonstrates that the pattern of FTD may include severe anterograde amnesia as a prominent and early consequence of the disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:23:57