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Titolo:
Serum uric acid and renal prognosis in patients with IgA nephropathy
Autore:
Ohno, I; Hosoya, T; Gomi, H; Ichida, K; Okabe, H; Hikita, M;
Indirizzi:
Jikei Univ, Sch Med, Dept Internal Med 2, Minato Ku, Tokyo 1058461, Japan Jikei Univ Tokyo Japan 1058461 al Med 2, Minato Ku, Tokyo 1058461, Japan
Titolo Testata:
NEPHRON
fascicolo: 4, volume: 87, anno: 2001,
pagine: 333 - 339
SICI:
0028-2766(200104)87:4<333:SUAARP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING ENZYME-INHIBITOR; RECEPTOR ANTAGONIST; NATURAL-HISTORY; RISK-FACTORS; HYPERTENSION; PROGRESSION; FAILURE; IMMUNOGLOBULIN; INSUFFICIENCY; WORLDWIDE;
Keywords:
serum uric acid; IgA nephropathy; hyperuricemia; renal prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Ohno, I Jikei Univ, Sch Med, Dept Internal Med 2, Minato Ku, 3-25-8 Nishi Shinbashi, Tokyo 1058461, Japan Jikei Univ 3-25-8 Nishi Shinbashi Tokyo Japan 1058461 8461, Japan
Citazione:
I. Ohno et al., "Serum uric acid and renal prognosis in patients with IgA nephropathy", NEPHRON, 87(4), 2001, pp. 333-339

Abstract

Background/Aims: This study was designed to elucidate the clinical significance of serum uric acid (SUA) and the relationship between hyperuricemia and renal prognosis in IgA nepropathy. Methods: The correlation between SUA and other clinical parameters were examined in 748 IgA nephropathy patients(432 males and 316 females). Among these patients, 226 (144 males and 82 females) who were followed for more than 5 years were examined for the relationship between hyperuricemia and renal prognosis. Results: In IgA nephropathy, SUA correlated negatively with creatinine clearance (Ccr), and positively with urinary protein and tubulointerstitial damage. SUA was higher in patients with hypertension or diffuse proliferative glomerulonephritis. Hyperuricemia was a risk factor for renal prognosis, both in terms of serum creatinine (p = 0.0025) and Ccr (p = 0.0057). In 56 patients with normal Ccr at renal biopsy, the change of Ccr after more than 8 years was -22.3 +/- 20.8% in 13 patients with hyperuricemia, compared with +2.6 +/- 39.4% in 43 patients without hyperuricemia (p = 0.0238), Hyperuricemia was related independently to deterioration of Ccr (p = 0.0461), Conclusion: Hyperuricemia in IgA nephropathy is derived from both glomerular and tubulointerstitial damage, and correlated with hypertension. Hyperuricemia is a risk factor for renal prognosis in IgA nephropathy. Copyright (C) 2001 S. Karger AG. Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:49:28