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Titolo:
The neuronal t-SNARE complex is a parallel four-helix bundle
Autore:
Xiao, WZ; Poirier, MA; Bennett, MK; Shin, YK;
Indirizzi:
Iowa State Univ, Dept Biochem & Biophys, Ames, IA 50011 USA Iowa State Univ Ames IA USA 50011 t Biochem & Biophys, Ames, IA 50011 USA Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 pt Chem, Berkeley, CA 94720 USA Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 ll Biol, Berkeley, CA 94720 USA
Titolo Testata:
NATURE STRUCTURAL BIOLOGY
fascicolo: 4, volume: 8, anno: 2001,
pagine: 308 - 311
SICI:
1072-8368(200104)8:4<308:TNTCIA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONFORMATIONAL-CHANGES; SYNAPTIC EXOCYTOSIS; STRUCTURAL-CHANGES; FUSION COMPLEX; SYNTAXIN; SNAP-25; PROTEIN; DOMAINS; BINDING; SSO1P;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Shin, YK Iowa State Univ, Dept Biochem & Biophys, Ames, IA 50011 USA Iowa State Univ Ames IA USA 50011 & Biophys, Ames, IA 50011 USA
Citazione:
W.Z. Xiao et al., "The neuronal t-SNARE complex is a parallel four-helix bundle", NAT ST BIOL, 8(4), 2001, pp. 308-311

Abstract

Assembly of the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) complex is an essential step for neurotransmitter release in synapses. The presynaptic plasma membrane associated-proteins (t-SNAREs), SNAP-25 (synaptosome-associated protein of 25,000 Da) and syntaxin 1A may form an intermediate complex that later binds to vesicle-associated membrane protein 2 (VAMP2), Using spin labeling electron paramagnetic resonance (EPR), we found that the two t-SNARE proteins assemble into a parallel four-helix bundle that consists of two identical syntaxin IA components and the N-terminal and C-terminal domains of SNAP-25, Although the structure is generally similar to that of the final SNARE complex, the middle region of the helical bundle appears more flexible in the t-SNARE complex, Such flexibility might facilitate interactions between VAMP2 and the t-SNARE complex.

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Documento generato il 20/01/21 alle ore 03:03:10