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Titolo:
A unified hypothesis on the lineage of neural stem cells
Autore:
Alvarez-Buylla, A; Garcia-Verdugo, JM; Tramontin, AD;
Indirizzi:
Univ Calif San Francisco, Dept Neurosurg Res, Koret Vis Res Labs, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Valencia, E-46100 Valencia, Spain Univ Valencia Valencia Spain E-46100 v Valencia, E-46100 Valencia, Spain
Titolo Testata:
NATURE REVIEWS NEUROSCIENCE
fascicolo: 4, volume: 2, anno: 2001,
pagine: 287 - 293
SICI:
1471-0048(200104)2:4<287:AUHOTL>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; ADULT MAMMALIAN BRAIN; CHICKEN OPTIC TECTUM; MURINE CEREBRAL WALL; RADIAL GLIAL-CELLS; SUBVENTRICULAR ZONE; NEURONAL MIGRATION; VENTRICULAR ZONE; DENTATE GYRUS; PRECURSOR CELLS;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
104
Recensione:
Indirizzi per estratti:
Indirizzo: Alvarez-Buylla, A Univ Calif San Francisco, Dept Neurosurg Res, Koret Vis Res Labs, Box 0520,K-130,10 Kirkham St, San Francisco, CA 94143 USA Univ Calif San Francisco Box 0520,K-130,10 Kirkham St San Francisco CA USA 94143
Citazione:
A. Alvarez-Buylla et al., "A unified hypothesis on the lineage of neural stem cells", NAT REV NEU, 2(4), 2001, pp. 287-293

Abstract

For many years, it was assumed that neurons and glia in the central nervous system were produced from two distinct precursor pools that diverged early during embryonic development. This theory was partially based on the ideathat neurogenesis and gliogenesis occurred during different periods of development, and that neurogenesis ceased perinatally. However. there is now abundant evidence that neural stem cells persist in the adult brain and support ongoing neurogenesis in restricted regions of the central nervous system. Surprisingly, these stem cells have the characteristics of fully differentiated glia. Neuroepithelial stem cells in the embryonic neural tube do not show glial characteristics, raising questions about the putative lineage from embryonic to adult stem cells. In the developing brain, radial glia have long been known to produce cortical astrocytes, but recent data indicatethat radial glia might also divide asymmetrically to produce cortical neurons. Here we review these new developments and propose that the stem cells in the central nervous system are contained within the neuroepithelial --> radial glia --> astrocyte lineage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 21:58:34