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Titolo:
Plasticity of motor systems after incomplete spinal cord injury
Autore:
Raineteau, O; Schwab, ME;
Indirizzi:
Univ Zurich, Brain Res Inst, CH-8057 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8057 Inst, CH-8057 Zurich, Switzerland ETH Zurich, CH-8057 Zurich, Switzerland ETH Zurich Zurich Switzerland CH-8057 urich, CH-8057 Zurich, Switzerland
Titolo Testata:
NATURE REVIEWS NEUROSCIENCE
fascicolo: 4, volume: 2, anno: 2001,
pagine: 263 - 273
SICI:
1471-0048(200104)2:4<263:POMSAI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURITE GROWTH-INHIBITORS; REORGANIZATION FOLLOWING MOTOR; MYELIN-ASSOCIATED GLYCOPROTEIN; LONG-TERM POTENTIATION; PYRAMIDAL TRACT LESION; CENTRAL-NERVOUS-SYSTEM; ADULT MACAQUE MONKEYS; FACTOR MESSENGER-RNA; RED NUCLEUS; FUNCTIONAL RECOVERY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
138
Recensione:
Indirizzi per estratti:
Indirizzo: Raineteau, O Univ Zurich, Brain Res Inst, Winterthurerstr 190, CH-8057 Zurich, Switzerland Univ Zurich Winterthurerstr 190 Zurich Switzerland CH-8057 d
Citazione:
O. Raineteau e M.E. Schwab, "Plasticity of motor systems after incomplete spinal cord injury", NAT REV NEU, 2(4), 2001, pp. 263-273

Abstract

Although spontaneous regeneration of lesioned fibres is limited in the adult central nervous system, many people that suffer from incomplete spinal cord injuries show significant functional recovery. This recovery process can go on for several years after the injury and probably depends on the reorganization of circuits that have been spared by the lesion. Synaptic plasticity in pre-existing pathways and the formation of new circuits through collateral sprouting of lesioned and unlesioned fibres are important components of this recovery process. These reorganization processes might occur in cortical and subcortical motor centres, in the spinal cord below the lesion,and in the spared fibre tracts that connect these centres. Functional and anatomical evidence exists that spontaneous plasticity can be potentiated by activity, as well as by specific experimental manipulations. These studies prepare the way to a better understanding of rehabilitation treatments and to the development of new approaches to treat spinal cord injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 10:04:01