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Titolo:
Cbl: Many adaptations to regulate protein tyrosine kinases
Autore:
Thien, CBF; Langdon, WY;
Indirizzi:
Univ Western Australia, Dept Pathol, Crawley, WA 6009, Australia Univ Western Australia Crawley WA Australia 6009 wley, WA 6009, Australia
Titolo Testata:
NATURE REVIEWS MOLECULAR CELL BIOLOGY
fascicolo: 4, volume: 2, anno: 2001,
pagine: 294 - 305
SICI:
1471-0072(200104)2:4<294:CMATRP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTOR; PHOSPHOTYROSINE-BINDING DOMAIN; PROTOONCOGENE C-CBL; MEDIATED NEGATIVE REGULATION; INTEGRIN SIGNALING PATHWAY; CELL ANTIGEN RECEPTOR; OF-FUNCTION MUTATION; ACTIVATED T-CELLS; ADAPTER PROTEIN; EGF RECEPTOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
112
Recensione:
Indirizzi per estratti:
Indirizzo: Langdon, WY Univ Western Australia, Dept Pathol, 35 Stirling Highway, Crawley, WA 6009, Australia Univ Western Australia 35 Stirling Highway Crawley WA Australia 6009
Citazione:
C.B.F. Thien e W.Y. Langdon, "Cbl: Many adaptations to regulate protein tyrosine kinases", NAT REV MOL, 2(4), 2001, pp. 294-305

Abstract

Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation of protein complexes that transmit signals throughout the cell. A prominent component of these complexes is the product of the proto-oncogenec-Cbl, which specifically targets activated protein tyrosine kinases and regulates their signalling. How, then, does this multidomain protein shape the responses generated by these signalling complexes?

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 09:28:02