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Titolo:
To ERR (meiotically) is human: The genesis of human aneuploidy
Autore:
Hassold, T; Hunt, P;
Indirizzi:
Case Western Reserve Univ, Dept Genet, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
NATURE REVIEWS GENETICS
fascicolo: 4, volume: 2, anno: 2001,
pagine: 280 - 291
SICI:
1471-0056(200104)2:4<280:TE(IHT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYLENETETRAHYDROFOLATE REDUCTASE GENE; MATERNAL RISK-FACTORS; DOWN-SYNDROME; HUMAN OOCYTES; CHROMOSOME SEGREGATION; MEIOSIS-I; SACCHAROMYCES-CEREVISIAE; DROSOPHILA-MELANOGASTER; FOLATE METABOLISM; SYNDROME CHILDREN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
85
Recensione:
Indirizzi per estratti:
Indirizzo: Hassold, T Case Western Reserve Univ, Dept Genet, 10900 Euclid Ave, Cleveland, OH 44106 USA Case Western Reserve Univ 10900 Euclid Ave Cleveland OH USA 44106
Citazione:
T. Hassold e P. Hunt, "To ERR (meiotically) is human: The genesis of human aneuploidy", NAT REV GEN, 2(4), 2001, pp. 280-291

Abstract

Aneuploidy (trisomy or monosomy) is the most commonly identified chromosome abnormality in humans. occurring in at least 5% of all clinically recognized pregnancies. Most aneuploid conceptuses perish in utero, which makes this the leading genetic cause of pregnancy loss. However, some aneuploid fetuses survive to term and, as a class, aneuploidy is the most common known cause of mental retardation. Despite the devastating clinical consequences of aneuploidy, relatively little is known of how trisomy and monosomy originate in humans. However, recent molecular and cytogenetic approaches are nowbeginning to shed light on the non-disjunctional processes that lead to aneuploidy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:32:42