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Titolo:
Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31
Autore:
Zenklusen, JC; Conti, CJ; Green, ED;
Indirizzi:
NHGRI, Genome Technol Branch, NIH, Bethesda, MD 20892 USA NHGRI Bethesda MD USA 20892 e Technol Branch, NIH, Bethesda, MD 20892 USA Univ Texas, MD Anderson Canc Ctr, Dept Carcinogenesis, Smithville, TX USA Univ Texas Smithville TX USA tr, Dept Carcinogenesis, Smithville, TX USA
Titolo Testata:
NATURE GENETICS
fascicolo: 4, volume: 27, anno: 2001,
pagine: 392 - 398
SICI:
1061-4036(200104)27:4<392:MAFART>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY BREAST-CANCER; COMMONLY DELETED REGION; LONG ARM; PHYSICAL MAP; OVARIAN-CANCER; SQUAMOUS-CELL; FREQUENT LOSS; HETEROZYGOSITY; HUMAN-CHROMOSOME-7; CARCINOMAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Zenklusen, JC NHGRI, Genome Technol Branch, NIH, Bethesda, MD 20892 USA NHGRI Bethesda MD USA 20892 ch, NIH, Bethesda, MD 20892 USA
Citazione:
J.C. Zenklusen et al., "Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31", NAT GENET, 27(4), 2001, pp. 392-398

Abstract

Loss of heterozygosity (LOH) of markers on human chromosome 7q31 is frequently encountered in a variety of human neoplasias, indicating the presence of a tumor-suppressor gene (TSC). By a combination of microcell-fusion and deletion-mapping studies, we previously established that this TSG resides within a critical region flanked by the genetic markers D7S522 and D7S677. Using a positional cloning strategy and aided by the availability of near-complete sequence of this genomic interval, we have identified a TSG within 7q31, named ST7 (for suppression of tumorigenicity 7; this same gene was recently reported in another context and called RAY1). ST7 is ubiquitously expressed in human tissues. Analysis of a series of cell lines derived from breast tumors and primary colon carcinomas revealed the presence of mutationsin ST7. Introduction of the ST7 cDNA into the prostate-cancer-derived cellline PC3 had no effect on the in vitro proliferation of the cells, but abrogated their in vivo tumorigenicity. Our data indicate that ST7 is a TSG within chromosome 7q31 and may have an important role in the development of some types of human cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:46:16