Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Leptin-regulated endocannabinoids are involved in maintaining food intake
Autore:
Di Marzo, V; Goparaju, SK; Wang, L; Liu, J; Batkai, S; Jarai, Z; Fezza, F; Miura, GI; Palmiter, RD; Sugiura, T; Kunos, G;
Indirizzi:
CNR, Ist Chim Mol Interesse Biol, Endocannabinoid Res Grp, I-80072 Arco Felice, Naples, Italy CNR Arco Felice Naples Italy I-80072 , I-80072 Arco Felice, Naples, Italy Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ghes Med Inst, Seattle, WA 98195 USA Univ Washington, Dept Biochem, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Biochem, Seattle, WA 98195 USA Teikyo Univ, Fac Pharmaceut Sci, Kanagawa 1990195, Japan Teikyo Univ Kanagawa Japan 1990195 armaceut Sci, Kanagawa 1990195, Japan
Titolo Testata:
NATURE
fascicolo: 6830, volume: 410, anno: 2001,
pagine: 822 - 825
SICI:
0028-0836(20010412)410:6830<822:LEAIIM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANIN-CONCENTRATING HORMONE; RECEPTOR MESSENGER-RNA; CANNABINOID-RECEPTOR; NEUROPEPTIDE-Y; RAT-BRAIN; MICE; CB1; HYPOTHALAMUS; ANTAGONIST; 2-ARACHIDONOYLGLYCEROL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kunos, G NIAAA, NIH, MSC-8115, Bethesda, MD 20892 USA NIAAA MSC-8115 Bethesda MD USA 20892 8115, Bethesda, MD 20892 USA
Citazione:
V. Di Marzo et al., "Leptin-regulated endocannabinoids are involved in maintaining food intake", NATURE, 410(6830), 2001, pp. 822-825

Abstract

Leptin is the primary signal through which the hypothalamus senses nutritional state and modulates food intake and energy balance(1). Leptin reduces food intake by upregulating anorexigenic (appetite-reducing) neuropeptides,such as a-melanocyte-stimulating hormone(2,3), and downregulating orexigenic (appetite-stimulating) factors, primarily neuropeptide Y-4. Genetic defects in anorexigenic signalling, such as mutations in the melanocortin-4 (ref. 5) or leptin receptors(6), cause obesity. However, alternative orexigenic pathways maintain food intake in mice deficient in neuropeptide Y-7. CB1 cannabinoid receptors(8) and the endocannabinoids anandamide and 2-arachidonoyl glycerol are present in the hypothalamus(9), and marijuana(10) and anandamide(11,12) stimulate food intake. Here we show that following temporaryfood restriction, CB1 receptor knockout mice eat less than their wild-typelittermates, and the CB1 antagonist SR141716A reduces food intake in wild-type but not knockout mice. Furthermore, defective leptin signalling is associated with elevated hypothalamic, but not cerebellar, levels of endocannabinoids in obese db/db and ob/ob mice and Zucker rats. Acute leptin treatment of normal rats and ob/ob mice reduces anandamide and 2-arachidonoyl glycerol in the hypothalamus. These findings indicate that endocannabinoids in the hypothalamus may tonically activate CB1 receptors to maintain food intake and form part of the neural circuitry regulated by leptin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:31:19