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Titolo:
Parkinson's disease with late Pick's dementia
Autore:
Henderson, JM; Gai, WP; Hely, MA; Reid, WGJ; Walker, GL; Halliday, GM;
Indirizzi:
Prince Wales Med Res Inst, Sydney, NSW, Australia Prince Wales Med Res Inst Sydney NSW Australia t, Sydney, NSW, Australia Flinders Med Ctr, Dept Physiol, Bedford Pk, SA, Australia Flinders Med Ctr Bedford Pk SA Australia siol, Bedford Pk, SA, Australia Westmead Hosp, Dept Neurol, Westmead, NSW, Australia Westmead Hosp Westmead NSW Australia pt Neurol, Westmead, NSW, Australia Prince Wales Hosp, Dept Psychiat, Randwick, NSW 2031, Australia Prince Wales Hosp Randwick NSW Australia 2031 ndwick, NSW 2031, Australia Westmead Neurol Ctr, Westmead, NSW, Australia Westmead Neurol Ctr Westmead NSW Australia Ctr, Westmead, NSW, Australia
Titolo Testata:
MOVEMENT DISORDERS
fascicolo: 2, volume: 16, anno: 2001,
pagine: 311 - 319
SICI:
0885-3185(200103)16:2<311:PDWLPD>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SUPRANUCLEAR PALSY; RICHARDSON-OLSZEWSKI SYNDROME; FRONTOTEMPORAL DEMENTIA; ALZHEIMERS-DISEASE; LEWY BODIES; DIAGNOSTIC-CRITERIA; SYDNEY MULTICENTER; LOCUS-CERULEUS; CONSENSUS; NEUROPSYCHOLOGY;
Keywords:
Pick bodies; Lewy bodies; alpha-synuclein; tau;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Henderson, JM Prince Wales Med Res Inst, Barker St, Randwick, NSW 2031, Australia Prince Wales Med Res Inst Barker St Randwick NSW Australia 2031
Citazione:
J.M. Henderson et al., "Parkinson's disease with late Pick's dementia", MOVEMENT D, 16(2), 2001, pp. 311-319

Abstract

We report a case in which typical clinical features of idiopathic Parkinson's disease existed for seven years prior to the development of significantbehavioral and cognitive changes and severe dementia. The patient presented with right-sided resting tremor. bradykinesia, and rigidity, which were highly responsive to levodopa. Serial neuropsychological evaluation revealedno evidence of dementia until late in the disease. The patient deteriorated rapidly eight years into the disease, requiring full care. She died 16 years after symptom onset and post-mortem neuropathological analysis revealedLewy body Parkinson's disease and Picks disease. To our knowledge, this isthe first non-familial case with this combination of clinical history and pathologically confirmed disease to be reported in the literature. The absence of a family history of any neurological disease sets this case apart from the recently described genetic cases of frontotemporal dementia with Parkinsonism linked to chromosome 17. In addition, the relatively late onset of dementia in frontotemporal dementia is atypical. While there is considerable debate regarding the cause of dementia in idiopathic Parkinson's disease, our case illustrates that Pick's disease is one such cause. (C) 2001 Movement Disorder Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:54:52