Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CYP2D6 polymorphism in Parkinson's disease: The Rotterdam study
Autore:
Harhangi, BS; Oostra, BA; Heutink, P; van Duijn, CM; Hofman, A; Breteler, MMB;
Indirizzi:
Erasmus Univ, Med Ctr, Dept Epidemiol & Biostat, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands Erasmus Med Ctr, Dept Clin Genet, Rotterdam, Netherlands Erasmus Med Ctr Rotterdam Netherlands lin Genet, Rotterdam, Netherlands
Titolo Testata:
MOVEMENT DISORDERS
fascicolo: 2, volume: 16, anno: 2001,
pagine: 290 - 293
SICI:
0885-3185(200103)16:2<290:CPIPDT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
POOR METABOLIZERS; DEBRISOQUINE; 4-HYDROXYLATION; SUSCEPTIBILITY;
Keywords:
Parkinson's disease; CYP2D6; genetics; epidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Breteler, MMB Erasmus Univ, Med Ctr, Dept Epidemiol & Biostat, POB 1738, NL-3000 DR Rotterdam, Netherlands Erasmus Univ POB 1738 Rotterdam Netherlands NL-3000 DR ands
Citazione:
B.S. Harhangi et al., "CYP2D6 polymorphism in Parkinson's disease: The Rotterdam study", MOVEMENT D, 16(2), 2001, pp. 290-293

Abstract

The CYP2D6 polymorphism has been studied extensively In association with Parkinson's disease (PD), with no consistent results. Several explanations, such as differences in study design or bias in the selection of the controlpopulation. have been offered for these inconsistent results. We designed a case control study nested within a prospective population-based cohort study in which cases and controls were sampled from the same source population. To assess the significance of the CYP2D6 gene in PD, we investigated twomutant alleles, CYP2D6*3 and CYP2D6*4. associated with poor metabolism andthe wild type allele in 80 patients with PD and 156 matched controls, frequency matched on age and gender. No differences between cases and controls were found for the poor metabolizer genotype. However, we found that in contrast to earlier reports, the CYP2D6*4 mutant allele frequency was lower incases as compared to controls, albeit not statistically significant. Our result supports the hypothesis that the CYP2D6 gene is not a major gene responsible for PD. (C) 2001 Movement Disorder Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:56:17