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Titolo:
Impairment of eyeblink classical conditioning in progressive supranuclear palsy
Autore:
Sommer, M; Grafman, J; Litvan, I; Hallett, M;
Indirizzi:
NINDS, Human Motor Control Sect, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 tor Control Sect, NIH, Bethesda, MD 20892 USA NINDS, Cognit Neurosci Sect, NIH, Bethesda, MD 20892 USA NINDS Bethesda MD USA 20892 it Neurosci Sect, NIH, Bethesda, MD 20892 USA
Titolo Testata:
MOVEMENT DISORDERS
fascicolo: 2, volume: 16, anno: 2001,
pagine: 240 - 251
SICI:
0885-3185(200103)16:2<240:IOECCI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
RICHARDSON-OLSZEWSKI-SYNDROME; CEREBRAL BLOOD-FLOW; CEREBELLAR DEGENERATION; PARKINSONS-DISEASE; REACTION-TIME; ABNORMALITIES; PERFORMANCE; DEMENTIA;
Keywords:
eyeblink classical conditioning; progressive supranuclear palsy (PSP); implicit and explicit memory; California verbal learning task (CVLT); serial reaction time task (SRTT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Hallett, M NINDS, Human Motor Control Sect, NIH, Bldg 10,Room 5 N226,10 Ctr Dr MSC 1428, Bethesda, MD 20892 USA NINDS Bldg 10,Room 5 N226,10 Ctr Dr MSC 1428 Bethesda MD USA 20892
Citazione:
M. Sommer et al., "Impairment of eyeblink classical conditioning in progressive supranuclear palsy", MOVEMENT D, 16(2), 2001, pp. 240-251

Abstract

In a previous study we showed that learning in eyeblink classical conditioning (EBCC) is normal in Parkinson's disease (PD) and that the serial reaction time task (SRTT) is only marginally impaired. Since pathological lesions are more widespread in the atypical parkinsonian disorder of progressive supranuclear palsy (PSP) than in PD, we hypothesized that PSP patients may show more profound deficits in the EBCC and SRTT learning tasks. We therefore investigated EBCC with a delay and two trace paradigms. an SRTT and the California Verbal Learning Test (CVLT) in eight patients with PSP and an age-matched control group. In all EBCC paradigms, we found a significant difference between groups with no significant learning in PSP patients. In the SRTT, implicit learning may have been impaired, but verbal and manual sequence recall were only marginally impaired. Verbal memory was significantly worse in PSP patients than in the control group. Our study shows a dissociated pattern of learning abilities in PSP, where the EBCC as a measure of implicit learning is impaired, the explicit sequence detection in the SRTT is relatively preserved, and the verbal memory impaired. We hypothesize that the PSP patients' deficits in EBCC learning may be due to lesions of deep cerebellar nuclei. There may be a clinical role for EBCC in distinguishing PDand PSP patients. (C) 2001 Movement Disorder Society.

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Documento generato il 20/01/20 alle ore 07:21:50