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Titolo:
Erythropoietin deficiency and anaemia in multiple system atrophy
Autore:
Winkler, AS; Marsden, J; Parton, M; Watkins, PJ; Chaudhuri, KR;
Indirizzi:
Univ London Kings Coll Hosp, Dept Clin Neurosci, Reg Movement Disorders & Dystonia Unit, London, England Univ London Kings Coll Hosp London England stonia Unit, London, England Univ London Kings Coll Hosp, Ctr Diabet, London, England Univ London KingsColl Hosp London England Ctr Diabet, London, England Univ London Kings Coll Hosp, Dept Biochem, London, England Univ London Kings Coll Hosp London England ept Biochem, London, England Univ London Kings Coll Hosp, Inst Psychiat, Motor Neurone Dis Clin, London, England Univ London Kings Coll Hosp London England ne Dis Clin, London, England
Titolo Testata:
MOVEMENT DISORDERS
fascicolo: 2, volume: 16, anno: 2001,
pagine: 233 - 239
SICI:
0885-3185(200103)16:2<233:EDAAIM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTONOMIC NERVOUS-SYSTEM; PARKINSONS-DISEASE; ANEMIA; PATHOGENESIS; DYSFUNCTION; FAILURE; RATS;
Keywords:
multiple system atrophy; anaemia; erythropoietin; postural hypotension;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Chaudhuri, KR Mapother House,Decrespigny Pk, London SE5 9RS, England Mapother House,Decrespigny Pk London England SE5 9RS gland
Citazione:
A.S. Winkler et al., "Erythropoietin deficiency and anaemia in multiple system atrophy", MOVEMENT D, 16(2), 2001, pp. 233-239

Abstract

Serum erythropoietin (EPO) levels are partially controlled by the sympathetic outflow to the kidney. We have studied whether patients with multiple system atrophy (MSA), known to be associated with dysautonomia. are EPO-deficient. Eighteen MSA patients were studied along with 32 idiopathic Parkinson's disease (PD) patients, 23 controls with iron-deficiency anaemia, and 18healthy individuals. Serum creatinine was normal in all groups. Mean haemoglobin (Hb) concentration in MSA patients was 13.7 +/- 1.7 g/dL. Four MSA patients had unexplained anaemia (minimum Hb: 10.5 g/dL) and abnormal autonomic function tests including significant postural hypotension, whereas noneof the PD patients was anaemic. Serum EPO levels were suppressed in relation to anaemia in MSA patients compared to elevated EPO levels in iron-deficiency anaemia patients (difference of regression lines P < 0.001), indicating EPO deficiency in the anaemic MSA patients. Serum EPO levels in PD patients were within normal range. A subset of MSA patients has anaemia and postural hypotension. which may be associated with EPO deficiency. This may have therapeutic implications. <(c)> 2001 Movement Disorder Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 03:03:44