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Titolo:
Does stimulation of the GPi control dyskinesia by activating inhibitory axons?
Autore:
Wu, YR; Levy, R; Ashby, P; Tasker, RR; Dostrovsky, JO;
Indirizzi:
Univ Toronto, Toronto Western Hosp, Playfair Neurosci Unit, Res Inst, Toronto, ON M5T 2S8, Canada Univ Toronto Toronto ON Canada M5T 2S8 Inst, Toronto, ON M5T 2S8, Canada Toronto Western Hosp, Div Neurosurg, Toronto, ON M5T 2S8, Canada Toronto Western Hosp Toronto ON Canada M5T 2S8 oronto, ON M5T 2S8, Canada Univ Toronto, Dept Physiol, Toronto, ON, Canada Univ Toronto Toronto ON Canada oronto, Dept Physiol, Toronto, ON, Canada Chang Gung Mem Hosp, Dept Neurol 2, Taipei 10591, Taiwan Chang Gung Mem Hosp Taipei Taiwan 10591 t Neurol 2, Taipei 10591, Taiwan
Titolo Testata:
MOVEMENT DISORDERS
fascicolo: 2, volume: 16, anno: 2001,
pagine: 208 - 216
SICI:
0885-3185(200103)16:2<208:DSOTGC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-FREQUENCY STIMULATION; HUMAN GLOBUS-PALLIDUS; PARKINSONS-DISEASE; POSTEROVENTRAL PALLIDOTOMY; FUNCTIONAL-ANATOMY; BASAL GANGLIA; SYMPTOMS; NEURONS; MONKEY;
Keywords:
dyskinesias; deep brain stimulation; globus pallidus internus; parkinsonism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Ashby, P Univ Toronto, Toronto Western Hosp, Playfair Neurosci Unit, Res Inst, 13-319,399 Bathurst St, Toronto, ON M5T 2S8, Canada Univ Toronto 13-319,399 Bathurst St Toronto ON Canada M5T 2S8 ada
Citazione:
Y.R. Wu et al., "Does stimulation of the GPi control dyskinesia by activating inhibitory axons?", MOVEMENT D, 16(2), 2001, pp. 208-216

Abstract

A 69-year-old woman with Parkinson's disease and levodopa-induced dyskinesias had a deep brain stimulation (DBS) electrode inserted into the right globus pallidus internus (GPi). During the operation, the GPI was mapped withdual microelectrode recordings. Stimulation through one microelectrode in GPI inhibited the firing of GPi neurons recorded with another microelectrode 600-1.000 mum distant. The inhibition could be obtained with pulse widthsof 150 mus and intensities as low as 10 muA. Single stimuli inhibited GPI neurons for similar to 50 ms. Trains of 300 Hz stimuli inhibited GPi neuronfiring almost completely. Postoperatively. stimulation through macroelectrode contacts located in the posterior ventral pallidum controlled the patient's dyskinesias. The effect could be obtained with pulse widths of 50 mus and frequencies as low as 70-80 Hz. We postulate stimulation of the ventralpallidum controls dyskinesias by activating large axons which inhibit GPi neurons. (C) 2001 Movement Disorder Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:38:59