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Titolo:
Reliability and validity of a new global dyskinesia rating scale in the MPTP-lesioned non-human primate
Autore:
Petzinger, GM; Quik, M; Ivashina, E; Jakowec, MW; Jakubiak, M; Di Monte, D; Langston, JW;
Indirizzi:
Univ So Calif, Keck Sch Med, Dept Neurol, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 Neurol, Los Angeles, CA 90033 USA Parkinsons Inst, Sunnyvale, CA USA Parkinsons Inst Sunnyvale CA USAParkinsons Inst, Sunnyvale, CA USA
Titolo Testata:
MOVEMENT DISORDERS
fascicolo: 2, volume: 16, anno: 2001,
pagine: 202 - 207
SICI:
0885-3185(200103)16:2<202:RAVOAN>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEVODOPA-INDUCED DYSKINESIAS; L-DOPA; PARKINSONIAN MONKEYS; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP; NIGROSTRIATAL DAMAGE; SQUIRREL-MONKEYS; TREATED MONKEYS; MODEL; HEMIPARKINSONISM; HYPOTHESIS;
Keywords:
Parkinson's disease; chorea; squirrel monkey; basal ganglia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Petzinger, GM Univ So Calif, Keck Sch Med, Dept Neurol, 1510 San Pablo St,Suite 268, LosAngeles, CA 90033 USA Univ So Calif 1510 San Pablo St,Suite 268 Los Angeles CA USA 90033
Citazione:
G.M. Petzinger et al., "Reliability and validity of a new global dyskinesia rating scale in the MPTP-lesioned non-human primate", MOVEMENT D, 16(2), 2001, pp. 202-207

Abstract

Behavioral rating scales for dyskinesia in the nonhuman primate are frequently used to assess the efficacy of new treatments and to provide a clinical correlative with neurochemical and neuropathological changes. Although a large variety of different scales have been used in non-human primate studies, there is no single standardized scale, and none have been evaluated forreliability and validity. We are reporting a new global non-human primate dyskinesia rating scale (GPDRS) for the squirrel monkey, developed in the context of an independent study of dyskinesia. In this report we demonstratethe reliability and validity of this scale. The GPDRS is a single-item scale with well-defined points and brevity allowing for rapid and easy application for assessing the overall degree of dyskinesia. In this study, seven MPTP-lesioned and four non-lesioned (control) non-human primates were videotaped following treatment with either levodopa or water. To test inter- and intra-rater reliability, three examiners rated the videotape independently at two different time points and these assessments were compared. The validity of the scale was tested in two phases. First, examiners rated the videotape using the GPDRS and the Abnormal Involuntary Movement Scale (AIMS), a scale commonly used to rate dyskinesia in the nonhuman primate, and the ratings from each scale were compared. Second, validity was tested in the context of an independent dyskinesia study, in which the scale was used to distinguish between two treatment groups. The GPDRS was shown to have high inter- and intra-rater reliability and to be valid for the assessment of dyskinesia in the squirrel monkey. In this report we also demonstrate the inter- and intra-rater reliability of the AIMS. (C) 2001 Movement Disorder Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 12:10:12