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Titolo:
Caspase-3 activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice
Autore:
Turmel, H; Hartmann, A; Parain, K; Douhou, A; Srinivasan, A; Agid, Y; Hirsch, EC;
Indirizzi:
Hop La Pitie Salpetriere, INSERM, U289, F-75013 Paris, France Hop La PitieSalpetriere Paris France F-75013 289, F-75013 Paris, France IDUN Pharmaceut Inc, La Jolla, CA USA IDUN Pharmaceut Inc La Jolla CA USA DUN Pharmaceut Inc, La Jolla, CA USA
Titolo Testata:
MOVEMENT DISORDERS
fascicolo: 2, volume: 16, anno: 2001,
pagine: 185 - 189
SICI:
0885-3185(200103)16:2<185:CAI1(>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINERGIC-NEURONS; PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; CELL-DEATH; DISTINCT MECHANISMS; APOPTOSIS; DEGENERATION; INHIBITION; RAT;
Keywords:
Parkinson's disease; MPTP; MPP+; apoptosis; caspase-3;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Hirsch, EC Hop La Pitie Salpetriere, INSERM, U289, 47 Blvd Hop, F-75013 Paris, France Hop La Pitie Salpetriere 47 Blvd Hop Paris France F-75013 ance
Citazione:
H. Turmel et al., "Caspase-3 activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice", MOVEMENT D, 16(2), 2001, pp. 185-189

Abstract

In 1-methyl-4-phenyl-1,2,3.6-tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1-methyl-4-phenylpyridinium (MPP+) may be mediated by caspase-3. To establish whether caspase-3 activation may indeed play a role in an in vivo model of PD, we studied caspase-3 activation in C57B1/6 mice: sub chronically intoxicated with MPTP. We show that caspase-3 activation peaks early, at days 1 and 2 after the end of MPTP intoxication. In contrast, pycnotic neurons persist until day 7 postintoxication, indicating that caspase-3 activation is an early and transient phenomenon in apoptotic death of DA neurons. We further demonstrate that loss of tyrosine hydroxylase (TH) immunoreactivity in this model is indeed due to cell loss rather than to loss of TH protein expression, We conclude that mice subchronically intoxicated with MPTP represent a valid PD model to study and manipulate caspase activation in vivo. (C) 2001 Movement Disorder Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:16:58