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Titolo:
Evolutionary history of microsatellites in the obscure group of Drosophila
Autore:
Noor, MAF; Kliman, RM; Machado, CA;
Indirizzi:
Louisiana State Univ, Dept Biol Sci, Baton Rouge, LA 70803 USA Louisiana State Univ Baton Rouge LA USA 70803 , Baton Rouge, LA 70803 USA Rutgers State Univ, Dept Genet, Piscataway, NJ 08855 USA Rutgers State Univ Piscataway NJ USA 08855 enet, Piscataway, NJ 08855 USA
Titolo Testata:
MOLECULAR BIOLOGY AND EVOLUTION
fascicolo: 4, volume: 18, anno: 2001,
pagine: 551 - 556
SICI:
0737-4038(200104)18:4<551:EHOMIT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPECIES GROUP; SLIPPAGE EVENTS; POINT MUTATIONS; SEQUENCES; PSEUDOOBSCURA; MELANOGASTER; LENGTH; DNA; INFORMATION; PHYLOGENIES;
Keywords:
microsatellites; simple sequence repeats; threshold; mutation; phylogenetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Noor, MAF Louisiana State Univ, Dept Biol Sci, 508 Life Sci Bldg, Baton Rouge, LA 70803 USA Louisiana State Univ 508 Life Sci Bldg Baton Rouge LA USA70803
Citazione:
M.A.F. Noor et al., "Evolutionary history of microsatellites in the obscure group of Drosophila", MOL BIOL EV, 18(4), 2001, pp. 551-556

Abstract

The evolutionary origins of microsatellites are not well understood. Some investigators have suggested that point mutations that expand repeat arraysbeyond a threshold size trigger microsatellites to become variable. However, little empirical data has been brought forth on this and related issues. In this study, we examine the evolutionary history of microsatellites in six species within the obscura group of Drosophila. tracing changes in microsatellite alleles using both PCR product size and sequence data. We found little evidence supporting a general role of point mutations triggering initial microsatellite expansion, and no consistent threshold size for expansion was observed. Flanking region length variation was extensive when alleleswere sequenced in distantly related species, and some species possessed altogether different repeat arrays between the same primer binding sites. Ourresults suggest extreme caution in using microsatellite allele sizes for phylogenetic analyses or to infer divergences between populations.

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Documento generato il 27/01/20 alle ore 01:25:48