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Titolo:
Two Cyp19 (P450 aromatase) genes on duplicated zebrafish chromosomes are expressed in ovary or brain
Autore:
Chiang, EFL; Yan, YL; Yann, GG; Postlethwait, J; Chung, BC;
Indirizzi:
Acad Sinica, Inst Mol Biol, Taipei 115, Taiwan Acad Sinica Taipei Taiwan115 Sinica, Inst Mol Biol, Taipei 115, Taiwan Inst Natl Rech Agron, Stn SCRIBE, Rennes, France Inst Natl Rech Agron Rennes France ch Agron, Stn SCRIBE, Rennes, France Univ Oregon, Inst Neurosci, Eugene, OR 97403 USA Univ Oregon Eugene OR USA 97403 egon, Inst Neurosci, Eugene, OR 97403 USA
Titolo Testata:
MOLECULAR BIOLOGY AND EVOLUTION
fascicolo: 4, volume: 18, anno: 2001,
pagine: 542 - 550
SICI:
0737-4038(200104)18:4<542:TC(AGO>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDAKA ORYZIAS-LATIPES; SALMON ONCORHYNCHUS-RHODURUS; VERTEBRATE GENOME EVOLUTION; CYTOCHROME-P450 AROMATASE; ESTROGEN BIOSYNTHESIS; SEQUENCE-ANALYSIS; MESSENGER-RNA; DANIO-RERIO; LINKAGE MAP; IDENTIFICATION;
Keywords:
zebrafish; gene duplication; cyp19; P450 aromatase; phylogeny; steroid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Chung, BC Acad Sinica, Inst Mol Biol, Taipei 115, Taiwan Acad Sinica Taipei Taiwan 115 nst Mol Biol, Taipei 115, Taiwan
Citazione:
E.F.L. Chiang et al., "Two Cyp19 (P450 aromatase) genes on duplicated zebrafish chromosomes are expressed in ovary or brain", MOL BIOL EV, 18(4), 2001, pp. 542-550

Abstract

Cytochrome P450 aromatase (Cyp19) is an enzyme catalyzing the synthesis ofestrogens, thereby controlling various physiological functions of estrogens. We isolated two cyp19 cDNAs, termed cyp19a and cyp19b, respectively, from zebrafish. These genes are located in linkage groups 18 and 25, respectively. Detailed gene mapping indicated that zebrafish linkage groups 18 and 25 may have arisen from the same ancestral chromosome by a chromosome duplication event. Cyp19a is expressed mainly in the follicular cells lining the vitellogenic oocytes in the ovary during vitellogenesis. Cyp19b is expressed abundantly in the brain, at the hypothalamus and ventral telencephalon, extending to the olfactory bulbs. The expression of duplicated cyp19 genes at two different tissues highlights the evolutionary significance of maintaining two active genes on duplicated zebrafish chromosomes for specific functions in the ovary and the brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:04:21