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Titolo:
Abnormalities of synapses and neurons in the hippocampus of neuropsin-deficient mice
Autore:
Hirata, A; Yoshida, S; Inoue, N; Matsumoto-Miyai, K; Ninomiya, A; Taniguchi, M; Matsuyama, T; Kato, K; Iizasa, H; Kataoka, Y; Yoshida, N; Shiosaka, S;
Indirizzi:
Nara Inst Sci & Technol, Div Struct Cell Biol, Nara, Japan Nara Inst Sci &Technol Nara Japan l, Div Struct Cell Biol, Nara, Japan Osaka Univ, Sch Med, Dept Anat & Neurosci, Osaka, Japan Osaka Univ OsakaJapan niv, Sch Med, Dept Anat & Neurosci, Osaka, Japan Hyogo Coll Med, Dept Internal Med 5, Nishinomiya, Hyogo, Japan Hyogo Coll Med Nishinomiya Hyogo Japan Med 5, Nishinomiya, Hyogo, Japan Kyoritsu Coll Pharm, Dept Pharmaceut, Tokyo, Japan Kyoritsu Coll Pharm Tokyo Japan ll Pharm, Dept Pharmaceut, Tokyo, Japan Univ Tokyo, Inst Med Sci, Ctr Med Expt, Tokyo, Japan Univ Tokyo Tokyo Japan Tokyo, Inst Med Sci, Ctr Med Expt, Tokyo, Japan
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 3, volume: 17, anno: 2001,
pagine: 600 - 610
SICI:
1044-7431(200103)17:3<600:AOSANI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; TISSUE-PLASMINOGEN ACTIVATOR; BINDING PROTEIN PARVALBUMIN; SERINE-PROTEASE; RAT HIPPOCAMPUS; MESSENGER-RNA; GABAERGIC NEURONS; DENTATE GYRUS; MOUSE-BRAIN; CA1 REGION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Hirata, A Nara Inst Sci & Technol, Div Struct Cell Biol, Nara, Japan Nara Inst Sci & Technol Nara Japan uct Cell Biol, Nara, Japan
Citazione:
A. Hirata et al., "Abnormalities of synapses and neurons in the hippocampus of neuropsin-deficient mice", MOL CELL NE, 17(3), 2001, pp. 600-610

Abstract

In the present study,we produced null-mutant mice of neuropsin, an extracellular matrix serine protease, to examine the neural functions of this protein particularly in the hippocampus. Golgi-Cox impregnation and NissI-staining revealed morphological change of cell soma in the mutant mice compared to wild-type mice. However, Golgi-Cox impregnation revealed no apparent change in the dendritic arborization and spine density. Quantitative electronmicroscopic analysis revealed that number of asymmetrical synapses were significantly decreased in the stratum radiatum, the major terminal field of Schaffer-collaterals, whereas free boutons still holding synaptic vesicles but with no synaptic specialization were increased in number in the same microscopic fields. An increased number of parvalbumin-immunoreactive cells (known as fast spiking cells) in mutant was also observed. These results strongly suggest that neuropsin is involved in connectivity of a group of CA1 synapses and consequently in the hippocampal networking.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:08:53