Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Correlation between putative inhibitory molecules at the dorsal root entryzone and failure of dorsal root axonal regeneration
Autore:
Zhang, Y; Tohyama, K; Winterbottom, JK; Haque, NSK; Schachner, M; Lieberman, AR; Anderson, PN;
Indirizzi:
Univ London Univ Coll, Dept Anat & Dev Biol, London WC1E 6BT, England UnivLondon Univ Coll London England WC1E 6BT , London WC1E 6BT, England Iwate Med Univ, Sch Med, Ctr Electron Microscopy & Bioimaging Res, Morioka, Iwate 020, Japan Iwate Med Univ Morioka Iwate Japan 020 ing Res, Morioka, Iwate 020, Japan Iwate Med Univ, Sch Med, Dept Cell Biol & Neuroanat, Morioka, Iwate 020, Japan Iwate Med Univ Morioka Iwate Japan 020 uroanat, Morioka, Iwate 020, Japan Univ Hamburg, Zentrum Mol Neurobiol, D-20246 Hamburg, Germany Univ Hamburg Hamburg Germany D-20246 Neurobiol, D-20246 Hamburg, Germany
Titolo Testata:
MOLECULAR AND CELLULAR NEUROSCIENCE
fascicolo: 3, volume: 17, anno: 2001,
pagine: 444 - 459
SICI:
1044-7431(200103)17:3<444:CBPIMA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHONDROITIN-SULFATE PROTEOGLYCAN; RAT SPINAL-CORD; TENASCIN-C EXPRESSION; O2A PROGENITOR CELLS; PDGF ALPHA-RECEPTOR; FIBERS IN-VITRO; EXTRACELLULAR-MATRIX; ADULT-RAT; SCIATIC-NERVE; NEURITE OUTGROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Zhang, Y Univ London Univ Coll, Dept Anat & Dev Biol, Gower St, London WC1E 6BT, England Univ London Univ Coll Gower St London England WC1E 6BT , England
Citazione:
Y. Zhang et al., "Correlation between putative inhibitory molecules at the dorsal root entryzone and failure of dorsal root axonal regeneration", MOL CELL NE, 17(3), 2001, pp. 444-459

Abstract

The molecular mechanisms involved in preventing regenerating dorsal root axons from entering the spinal cord at the dorsal root entry zone (DREZ) areobscure. We used immunohistochemistry, in situ hybridization, and electronmicroscopy to study axonal regeneration after dorsal rhizotomy in adult rats and its relationship to cellular changes and the distribution of putative growth inhibitory molecules in this region. Astrocyte processes, ending as bulb-shaped expansions, grew up to 700 mum into the basal lamina tubes ofinjured roots, where regenerating axons were also present. Some of these axons approached or reached the DREZ but grew no further; others turned backtoward the ganglion, suggesting the presence of repulsive cues in or near the DREZ. Tenascin-C mRNA and protein and CSPG stub immunoreactivity were strongly upregulated in the roots after rhizotomy, but were only weakly expressed in the DREZ. Tenascin-R immunoreactivity was confined to CNS tissue, and unaffected by rhizotomy. Large, rounded GFAP-negative, NG2-immunoreactive cells, a few of which were OX42 positive, were found in the DREZ following rhizotomy. Astrocyte processes projecting into the roots were tenascin-Rand NG2 negative. Hence, only NG2-expressing cells and tenascin-R were appropriately situated to inhibit regeneration through the DREZ.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:53:07