Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
TNF alpha is required for hypoxia-mediated right ventricular hypertrophy
Autore:
Smith, RM; McCarthy, J; Sack, MN;
Indirizzi:
Univ Cape Town, Sch Med, Hatter Inst Cardiol Res, MRC Interuniv Cape HeartGrp, ZA-7925 Cape Town, South Africa Univ Cape Town Cape Town South Africa ZA-7925 25 Cape Town, South Africa
Titolo Testata:
MOLECULAR AND CELLULAR BIOCHEMISTRY
fascicolo: 1-2, volume: 219, anno: 2001,
pagine: 139 - 143
SICI:
0300-8177(200103)219:1-2<139:TAIRFH>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; PULMONARY FIBROSIS; HEART-FAILURE; CARDIAC FIBROBLASTS; PROTEIN EXPRESSION; MICE; STRESS; GENE; RATS;
Keywords:
hypobaric hypoxia; TNF alpha; right-ventricular hypertrophy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Sack, MN Univ Cape Town, Sch Med, Hatter Inst Cardiol Res, MRC Interuniv Cape HeartGrp, ZA-7925 Cape Town, South Africa Univ Cape Town Cape Town South Africa ZA-7925 own, South Africa
Citazione:
R.M. Smith et al., "TNF alpha is required for hypoxia-mediated right ventricular hypertrophy", MOL C BIOCH, 219(1-2), 2001, pp. 139-143

Abstract

Hypoxia has been shown to activate the pleiotropic cytokine TNF alpha in the lung. TNF alpha in turn, is known to induce pulmonary vasoconstriction. Additional effects of this cytokine in hypoxia mediated cardiopulmonary remodeling are poorly understood. To further evaluate the role of TNF alpha inchronic hypoxia we exposed TNF alpha null (TNF alpha-/-) and wild-type mice to three weeks of hypobaric hypoxia (10% O-2). Equivalent erythocytosis (Hematocrit increased by greater than or equal to 40%) developed in both genetic backgrounds. In contrast, right ventricular systolic pressure increased in response to three weeks of hypoxia in the wild-type mice (greater thanor equal to 75%), yet was unaltered in the TNF alpha-/- mice. Concomitantly right ventricular hypertrophy was attenuated in the TNF alpha-/- mice (35+/- 5% increase) when compared to wild-type mice (124 +/- 6% increase p < 0.001, n greater than or equal to 20). Interestingly in both strains the lung wet weights increased to a similar degree in response to hypoxia. In conclusion, our data demonstrate that TNF alpha is an integral autocoid in chronic hypoxia mediated right ventricular hypertrophy. Moreover, additional components of cardiopulmonary remodeling may be regulated by TNF alpha signaling as suggested by the negligible right ventricular systolic pressure response to hypoxia in the absence of TNF alpha.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:45:00