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Titolo:
In vitro activity of 19 antimicrobial agents against enterococci from healthy subjects and hospitalized patients and use of an ace gene probe from Enterococcus faecalis for species identification
Autore:
Duh, RW; Singh, KV; Malathum, K; Murray, BE;
Indirizzi:
Univ Texas, Sch Med, Ctr Study Emerging & Reemerging Pathogens, Div InfectDis, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 ens, Div InfectDis, Houston, TX 77030 USA Univ Texas, Sch Med, Dept Internal Med, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 Dept Internal Med, Houston, TX 77030 USA Univ Texas, Sch Med, Dept Microbiol & Mol Genet, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 robiol & Mol Genet, Houston, TX 77030 USA Vet Gen Hosp, Dept Med, Infect Dis Sect, Taipei, Taiwan Vet Gen Hosp Taipei Taiwan p, Dept Med, Infect Dis Sect, Taipei, Taiwan Natl Yang Ming Univ, Dept Med, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 Univ, Dept Med, Taipei 112, Taiwan Ramathibodi Hosp, Dept Internal Med, Div Infect Dis, Bangkok, Thailand Ramathibodi Hosp Bangkok Thailand ed, Div Infect Dis, Bangkok, Thailand
Titolo Testata:
MICROBIAL DRUG RESISTANCE-MECHANISMS EPIDEMIOLOGY AND DISEASE
fascicolo: 1, volume: 7, anno: 2001,
pagine: 39 - 46
SICI:
1076-6294(200121)7:1<39:IVAO1A>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESISTANT ENTEROCOCCUS; FAECIUM; SUSCEPTIBILITY; NOVOBIOCIN; COMMUNITY; FEED;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Singh, KV Univ Texas, Sch Med, Ctr Study Emerging & Reemerging Pathogens, Div InfectDis, 6431 Fannin,1-728 JFB, Houston, TX 77030 USA Univ Texas 6431Fannin,1-728 JFB Houston TX USA 77030 77030 USA
Citazione:
R.W. Duh et al., "In vitro activity of 19 antimicrobial agents against enterococci from healthy subjects and hospitalized patients and use of an ace gene probe from Enterococcus faecalis for species identification", MICROB DR R, 7(1), 2001, pp. 39-46

Abstract

We tested 165 enterococcal isolates, biased toward vancomycin resistant (VR) isolates, collected during recent years from fecal samples of healthy subjects and clinical specimens of hospitalized patients (mostly from United States and some from Europe) for susceptibility to 19 antimicrobials, Nosocomial isolates, whether VR or not, were more often highly resistant to aminoglycosides and clindamycin than fecal isolates from healthy community volunteers and more often resistant to erythromycin, chloramphenicol, trimethoprim, levofloxacin and, for E, faecium, ampicillin (93 vs, 0%). Resistance rates were similar between nosocomial and community-fecal isolates for minocycline, rifampin and quinupristin-dalfopristin (Q-D), None of the 165 enterococci tested hybridized with aph(2 ' ')-Ic and aph(2 ' ')-Id probes for recently described gentamicin resistance genes and 37 of the 39 isolates withhigh level resistance (HLR) to gentamicin hybridized with an intragenic aac(6 ' )aph(2 ' ') probe. Of the two newer drugs tested, daptomycin MIC(90)swere 0.25 mug/mL for E. faecalis and 1 mug/mL for E. faecium, regardless of their vancomycin resistance level or source. For Q-D, none of 28 E. faecium from community based healthy subjects in the USA and 7 of 66 E, faecium from hospitalized patients in the United States were resistant. Among these7 Q-D-r United States isolates and 7 Q-D-r isolates from Europe (MICs of Q-D of 4-8 mug/mL), none hybridized with vat(D) (formerly satA) and vat(E) (formerly satG) DNA probes, indicating the involvement of other mechanism/s of resistance in these isolates. We also demonstrated that an intragenic probe of the gene ace from E. faecalis showed specific hybridizations to all E. faecalis isolates, suggesting the usefulness of this gene for identification of this species.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:26:16