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Titolo:
Dynamic contrast-enhanced MRI of experimental spinal cord injury: In vivo serial studies
Autore:
Bilgen, M; Abbe, R; Narayana, PA;
Indirizzi:
Univ Texas, Sch Med, Dept Radiol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 h Med, Dept Radiol, Houston, TX 77030 USA
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 4, volume: 45, anno: 2001,
pagine: 614 - 622
SICI:
0740-3194(200104)45:4<614:DCMOES>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO; TEMPORAL EVOLUTION; WHITE-MATTER; GRAY-MATTER; TIME COURSE; BARRIER; MODEL;
Keywords:
spinal cord injury; dynamic contrast-enhanced MRI; angiogenesis; Gd-DTPA; gadopentate dimeglumine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Bilgen, M Univ Texas, Sch Med, Dept Radiol, 6431 Fannin, Houston, TX 77030USA Univ Texas 6431 Fannin Houston TX USA 77030 ouston, TX 77030 USA
Citazione:
M. Bilgen et al., "Dynamic contrast-enhanced MRI of experimental spinal cord injury: In vivo serial studies", MAGN RES M, 45(4), 2001, pp. 614-622

Abstract

The progression of experimental spinal cord injury (SCI) was followed within vivo dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) andneurobehavioral studies on postinjury days 0, 2, 4, 7, 10, 14, 17, 21, 28,35, and 42, Gadopentate dimeglumine (Gd) was administered IV and postcontrast, T-1-weighted, axial images were acquired repetitively for up to 60 min, Images were analyzed to determine the spatial and temporal evolution of the intensity enhancement. A statistical decision mechanism was developed toobjectively detect the enhancement. Strong and rapid enhancement was observed at the epicenter of injury, indicating a significant compromise in blood spinal cord barrier. The enhanced regions in each slice were combined to estimate the area and volume of the lesion, On the day of injury, around 85% of the total cord area at the epicenter showed enhancement within the first 15 min of Gd administration. At the same time, the enhanced volumes attained nearly 40% of the total cord volume and extended axially over 8 mm along the cord. These quantities decreased steadily with time, with a concomitant improvement in the motor functions. The volume of enhancement correlated highly with the neurobehavioral tests (r = -0.87). DCE-MRIs revealed small hyperintense regions distributed inside white matter about two weeks postinjury. Based on histology, these enhancements appear to represent new vessels with "leaky endothelium. " Magn Reson Med 45:614-622, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:29:57